Citation: Zhang Xuzhi, Yang Qianqian, Zhang Xuchang, Wang Pingping, Hao Zhihui, Zhao Jun, Qu Keming. High-throughput measurements of ciprofloxacin, clomipramine and fexofenadine hydrochlorides with an 8-channel electrical titrator[J]. Chinese Chemical Letters, ;2018, 29(9): 1391-1394. doi: 10.1016/j.cclet.2017.11.005 shu

High-throughput measurements of ciprofloxacin, clomipramine and fexofenadine hydrochlorides with an 8-channel electrical titrator

a.
Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China
b.
Department of Hematology, Longgang District People's Hospital, Shenzhen 518172, China
c.
School of Chemistry and Pharmaceutical Sciences, Qingdao Agriculture University, Qingdao 266109, China

Corresponding author: Hao Zhihui, abplab@126.com Qu Keming, qukm@ysfri.ac.cn
Received Date: 21 September 2017
Revised Date: 3 November 2017
Accepted Date: 6 November 2017
Available Online: 10 September 2017

Figures(3)

High-throughput measurements of ciprofloxacin, clomipramine and fexofenadine hydrochlorides were performed by employing an automatic 8-channel electrical titrator. Silver nitrate (AgNO₃) and sodium tetraphenylborate (NaTPB) were used as titrants. When AgNO₃ was used for measuring the drugs in pure form, recoveries were 97.6%-102.0% with RSD values ≤ 1.0%; for measuring them in pharmaceutical formulations, recoveries were 96.6%-99.1% with RSD values ≤ 1.0%. Batch samples of eight could be measured simultaneously and maximally 30 measurements per minute could be completed. When NaTPB was used for measuring the drugs in pure form, the recoveries were 96.8%-102.6% with RSD values ≤ 0.8%; for measuring them in pharmaceutical formulations, the recoveries were 97.5%-102.7% with RSD values ≤ 0.9%. For all analyses, no auxiliary devices or chemicals were needed and there was no requirement for changing or cleaning working electrodes between measurements. The efficiency, accuracy and precision of the proposed method make it an alternative for routine quality control analyses.
- Eight-channel electrical titrator,
- Ciprofloxacin hydrochloride,
- Clomipramine hydrochloride,
- Fexofenadine hydrochloride,
- High throughput measurement,
- Pharmaceutical analysis
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1.
沈阳化工大学材料科学与工程学院沈阳 110142