Citation: Yang Ruige, Guo Yong, Zhang Yuanyuan, Xu Hui. Semisynthesis of new ethers from furyl-ring-based acylation derivatives of fraxinellone as insecticidal agents against Mythimna separata Walker in vivo[J]. Chinese Chemical Letters, ;2018, 29(6): 995-997. doi: 10.1016/j.cclet.2017.10.018 shu

Semisynthesis of new ethers from furyl-ring-based acylation derivatives of fraxinellone as insecticidal agents against Mythimna separata Walker in vivo

Yang Ruige ^a,1 ,
Guo Yong ^a,1 ,
Zhang Yuanyuan ^a ,
Xu Hui ^a,b,,

a.
Research Institute of Pesticidal Design & Synthesis, and Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A & F University, Yangling 712100, China
b.
College of Plant Protection, Northwest A & F University, Yangling 712100, China

Corresponding author: Xu Hui, orgxuhui@nwsuaf.edu.cn

Received Date: 24 April 2017
Revised Date: 12 October 2017
Accepted Date: 16 October 2017
Available Online: 18 June 2017

Figures(3)

Fraxinellone, a naturally occurring degraded limonoid, is mainly isolated from Dictamnus dasycarpus and Melia azedarach. In continuation of our program aimed at the discovery of plant natural products-based insecticidal agents, twenty-two new ethers from furyl-ring-based acylation derivatives were prepared by structural modifications of fraxinellone. Their insecticidal activity was evaluated against the pre-thirdinstar larvae of Mythimna separata Walker in vivo. Among them, compounds 5e and 5j exhibited more potent insecticidal activity than toosendanin with the final mortality rates greater than 60%. Their structure-activity relationships were also discussed.
- Fraxinellone,
- Ethers,
- Furyl ring,
- Insecticidal activity,
- Mythimna separata Walker
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