Citation: Yang Xiaotong, Zhong Zhi, Xu Jun, Huang Yanbin. Drug-polymer inclusion complex as a new pharmaceutical solid form[J]. Chinese Chemical Letters, ;2017, 28(11): 2099-2104. doi: 10.1016/j.cclet.2017.09.049 shu

Drug-polymer inclusion complex as a new pharmaceutical solid form

Key Laboratory of Advanced Materials(MOE), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China

Author Bio:

Yanbin Huang received his B.S. and M.S. both in polymer materials from Tsinghua University (in 1994 and 1997, respectively), and his Ph.D. in chemical engineering from Purdue University in 2001. He had worked at KimberlyClark Corporation (2001–2004) and ALZA Corporation (a Johnson & Johnson Company, 2004–2007) before joined the Department of Chemical Engineering, Tsinghua University in 2007 as an Associate Professor. His research interests are drug delivery and biomedical polymers
Corresponding author: Huang Yanbin, yanbin@tsinghua.edu.cn
Received Date: 17 August 2017
Revised Date: 22 September 2017
Accepted Date: 22 September 2017
Available Online: 22 November 2017

Figures(7)

The solid forms of drugs play a central role in controlling their physicochemical properties and consequently the bioavailability. Multiple types of drug solid forms have been developed to achieve the desirable pharmaceutical profiles, but new solid forms will provide more options for the solid-state property optimization and hence are highly desirable. This review focuses on a new pharmaceutical solid form, drug-polymer inclusion complexes (ICs), and summarizes their structural features, structureproperty relationships, as well as potential pharmaceutical applications
- Pharmaceutical solid forms,
- Crystalline inclusion complex,
- Thermal stability,
- Dissolution profiles,
- Homopolymers,
- Block copolymers
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