Citation: Zhou Zhifang, Lin Han, Li Chen, Wu Zhimeng. Recent progress of fully synthetic carbohydrate-based vaccine using TLR agonist as build-in adjuvant[J]. Chinese Chemical Letters, ;2018, 29(1): 19-26. doi: 10.1016/j.cclet.2017.09.047 shu

Recent progress of fully synthetic carbohydrate-based vaccine using TLR agonist as build-in adjuvant

Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China

Corresponding author: Wu Zhimeng, zhimengw@hotmail.com; zwu@jiangnan.edu.cn
Received Date: 30 June 2017
Revised Date: 18 August 2017
Accepted Date: 21 September 2017
Available Online: 22 January 2017

Figures(13)

Fully synthetic vaccine, in which one or multi-molecular antigens are conjugated to a synthetic carrier with well-defined chemical structure, is a new direction to develop carbohydrate-based vaccine against cancer and pathogens. Toll like receptor (TLR) agonists with the ability to stimulate immune response have been widely investigated and been applied as build-in adjuvants to construct fully synthetic vaccines. In particular, remarkable progress has been achieved in recent years in the development of vaccines constructed with the agonists of TLR1/2, TLR2/6 and TLR4 and tumor-associated carbohydrate antigens (TACAs). These di-, tri-or multi-component vaccine candidates showed attractive immunological properties. This review highlights recent advances in developing full synthetic carbohydrate antigen based vaccines, with an emphasis on the structure-activity relationships that provide a primary basis for future vaccine design and immunotherapy developing.
- Fully synthetic vaccine,
- TLR agonist,
- Build-in adjuvant,
- Carbohydrate-based vaccine,
- TACAs
1. [1]
  R.D. Astronomo, D.R. Burton, Nat. Rev. Drug. Discov. 9(2010) 308-324. doi: 10.1038/nrd3012
2. [2]
  B.L. Bartlett, A.J. Pellicane, S.K. Tyring, Dermatol. Ther. 22(2009) 104-109. doi: 10.1111/dth.2009.22.issue-2
3. [3]
  Z. Guo, Q. Wang, Curr. Opin. Chem. Biol. 13(2009) 608-617. doi: 10.1016/j.cbpa.2009.08.010
4. [4]
  D. Feng, A.S. Shaikh, F. Wang, ACS Chem. Biol. 11(2016) 850-863. doi: 10.1021/acschembio.6b00084
5. [5]
  T. Buskas, Y. Li, G.J. Boons, J. Chem. Eur. 10(2004) 3517-3524. doi: 10.1002/(ISSN)1521-3765
6. [6]
  T. Buskas, S. Ingale, G.J. Boons, Angew. Chem. Int. Ed. 44(2005) 5985-5988. doi: 10.1002/(ISSN)1521-3773
7. [7]
  C. Anish, B. Schumann, C.L. Pereira, P.H. Seeberger, Chem. Biol. 21(2014) 38-50. doi: 10.1016/j.chembiol.2014.01.002
8. [8]
  R.L. Coffman, A. Sher, R.A. Seder, Immunity 33(2010) 492-503. doi: 10.1016/j.immuni.2010.10.002
9. [9]
  M. Hedayat, K. Takeda, N. Rezaei, Med. Res. Rev. 32(2012) 294-325. doi: 10.1002/med.2012.32.issue-2
10. [10]
  T.P. Hopp, Mol. Immunol. 21(1984) 13-16. doi: 10.1016/0161-5890(84)90084-1
11. [11]
  B.D. Livingston, C. Crimi, H. Grey, et al., J. Immunol. 159(1997) 1383-1392.
12. [12]
  A. Vitiello, G. Ishioka, H.M. Grey, et al., J. Clin. Invest. 95(1995) 341-349. doi: 10.1172/JCI117662
13. [13]
  J. Metzger, K.H. Wiesmuller, R. Schaude, W.G. Bessler, G. Jung, Int. J. Pept. Protein Res. 37(1991) 46-57.
14. [14]
  T. Toyokuni, S. Hakomori, A.K. Singhal, Bioorg. Med. Chem. 2(1994) 1119-1132. doi: 10.1016/S0968-0896(00)82064-7
15. [15]
  V. Kudryashov, P.W. Glunz, L.J. Williams, et al., Proc. Natl. Acad. Sci. U. S. A. 98(2001) 3264-3269. doi: 10.1073/pnas.051623598
16. [16]
  M.A. Cheever, J.P. Allison, A.S. Ferris, et al., Clin. Cancer Res. 15(2009) 5323-5337. doi: 10.1158/1078-0432.CCR-09-0737
17. [17]
  N. Gaidzik, U. Westerlind, H. Kunz, Chem. Soc. Rev. 42(2013) 4421-4442. doi: 10.1039/c3cs35470a
18. [18]
  S. Ingale, M.A. Wolfert, J. Gaekwad, T. Buskas, G.J. Boons, Nat. Chem. Biol. 3(2007) 663-667. doi: 10.1038/nchembio.2007.25
19. [19]
  V. Lakshminarayanan, P. Thompson, M.A. Wolfert, et al., Proc. Natl. Acad. Sci. U. S. A. 109(2012) 261-266. doi: 10.1073/pnas.1115166109
20. [20]
  P. Thompson, V. Lakshminarayanan, N.T. Supekar, et al., Chem. Commun. 51(2015) 10214-10217. doi: 10.1039/C5CC02199E
21. [21]
  H. Cai, Z.Y. Sun, Z.H. Huang, et al., Chem. Eur. J. 19(2013) 1962-1970. doi: 10.1002/chem.v19.6
22. [22]
  H. Cai, M.S. Chen, Z.Y. Sun, et al., Angew. Chem. Int. Ed. 52(2013) 6106-6110. doi: 10.1002/anie.201300390
23. [23]
  H. Cai, Z.Y. Sun, M.S. Chen, et al., Angew. Chem. Int. Ed. 53(2014) 1699-1703. doi: 10.1002/anie.201308875
24. [24]
  H. Cai, Z.H. Huang, L. Shi, et al., Chem. Eur. J. 17(2011) 6396-6406. doi: 10.1002/chem.201100217
25. [25]
  B.L. Wilkinson, S. Day, L.R. Malins, V. Apostolopoulos, R.J. Payne, Angew. Chem. Int. Ed. 50(2011) 1635-1639. doi: 10.1002/anie.201006115
26. [26]
  B.L. Wilkinson, L.R. Malins, C.K. Chun, R.J. Payne, Chem. Commun. 46(2010) 6249-6251. doi: 10.1039/c0cc01360a
27. [27]
  B.L. Wilkinson, S. Day, R. Chapman, et al., Chem. Eur. J. 18(2012) 16540-16548. doi: 10.1002/chem.201202629
28. [28]
  D.M. McDonald, B.L. Wilkinson, L. Corcilius, et al., Chem. Commun. 50(2014) 10273-10276. doi: 10.1039/C4CC03510K
29. [29]
  P.F. Muhlradt, M. Kiess, H. Meyer, R. Sussmuth, G. Jung, J. Exp. Med. 185(1997) 1951-1958. doi: 10.1084/jem.185.11.1951
30. [30]
  Y. Liu, W. Zhang, Q. He, et al., Chem. Commun. 52(2016) 10886-10889. doi: 10.1039/C6CC04623A
31. [31]
  O. Renaudet, G. Dasgupta, I. Bettahi, et al., PloS One 5(2010) e11216. doi: 10.1371/journal.pone.0011216
32. [32]
  C. Geraci, G.M. Consoli, G. Granata, et al., Bioconjug. Chem. 24(2013) 1710-1720. doi: 10.1021/bc400242y
33. [33]
  A.B.M. Abdel-Aal, D. El-Naggar, M. Zaman, M. Batzloff, I. Toth, J. Med. Chem. 55(2012) 6968-6974. doi: 10.1021/jm300822g
34. [34]
  B.S. Park, D.H. Song, H.M. Kim, et al., Nature 458(2009) 1191-1195. doi: 10.1038/nature07830
35. [35]
  E.T. Rietschel, T. Kirikae, F.U. Schade, et al., FASEB J. 8(1994) 217-225.
36. [36]
  C.H. Marzabadi, R.W. Franck, J. Chem Eur, 23(2017) 1728-1742. doi: 10.1002/chem.v23.8
37. [37]
  Q. Wang, Z. Zhou, S. Tang, Z. Guo, ACS Chem. Biol. 7(2012) 235-240. doi: 10.1021/cb200358r
38. [38]
  Q. Wang, J. Zhang, Z. Guo, Bioorg. Med. Chem. 15(2007) 7561-7567. doi: 10.1016/j.bmc.2007.09.005
39. [39]
  Z. Zhou, G. Liao, S. Stepanovs, Z. Guo, J. Carbohydr. Chem. 33(2014) 395-407. doi: 10.1080/07328303.2014.933483
40. [40]
  L. Qiu, J. Li, S. Yu, et al., Oncotarget 6(2015) 5195-5203.
41. [41]
  Z. Zhou, M. Mondal, G. Liao, Z. Guo, Org. Biomol. Chem. 12(2014) 3238-3245. doi: 10.1039/C4OB00390J
42. [42]
  Z. Zhou, G. Liao, S.S. Mandal, S. Suryawanshi, Z. Guo, Chem. Sci. 6(2015) 7112-7121. doi: 10.1039/C5SC01402F
43. [43]
  S.J. Danishefsky, Y.K. Shue, M.N. Chang, C.H. Wong, Acc. Chem. Res. 48(2015) 643-652. doi: 10.1021/ar5004187
44. [44]
  F. Burkhart, Z. Zhang, S. Wacowich-Sgarbi, C.H. Wong, Angew. Chem. 40(2001) 1274-1277. doi: 10.1002/(ISSN)1521-3773
45. [45]
  Y.L. Huang, J.T. Hung, S.K. Cheung, et al., Proc. Natl. Acad. Sci. U. S. A. 110(2013) 2517-2522. doi: 10.1073/pnas.1222649110
46. [46]
  S.S. Mandal, G. Liao, Z. Guo, RSC Adv. 5(2015) 23311-23319. doi: 10.1039/C5RA00759C
47. [47]
  G. Liao, Z. Zhou, Z. Guo, Chem. Commun. 51(2015) 9647-9650. doi: 10.1039/C5CC01794G
48. [48]
  G. Liao, Z. Zhou, S. Suryawanshi, M.A. Mondal, Z. Guo, ACS Cent. Sci. 2(2016) 210-218. doi: 10.1021/acscentsci.5b00364
49. [49]
  J.D. Lewicky, M. Ulanova, Z.H. Jiang, Chem. Select 1(2016) 906-910.
50. [50]
  J. Schettini, A. Kidiyoor, D.M. Besmer, et al., Cancer Immunol. Immunother. 61(2012) 2055-2065. doi: 10.1007/s00262-012-1264-y
51. [51]
  P. Daftarian, R. Sharan, W. Haq, et al., Vaccine 23(2005) 3453-3468. doi: 10.1016/j.vaccine.2005.01.093
52. [52]
  A.M. Abdel-Aal, V. Lakshminarayanan, P. Thompson, et al., Chembiochem 15(2014) 1508-1513. doi: 10.1002/cbic.201402077
53. [53]
  N.M. Shukla, T.C. Lewis, T.P. Day, et al., Bioorg. Med. Chem. Lett. 21(2011) 3232-3236. doi: 10.1016/j.bmcl.2011.04.050
54. [54]
  G.M. Lynn, R. Laga, P.A. Darrah, et al., Nat. Biotechnol. 33(2015) 1201-1210. doi: 10.1038/nbt.3371
1. [1]
  Yuxin Tian , Mengjun Li , Yang Yang , Chunhui Li , Yun Peng , Haiyin Yang , Mengyuan Zhao , Pengfei Wu , Shaobo Ruan , Yuanyu Huang , Chenguang Shen , Minghui Yang . An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus. Chinese Chemical Letters, 2024, 35(8): 109270-. doi: 10.1016/j.cclet.2023.109270
2. [2]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
3. [3]
  Kun Liu , Yulin Cong , Xiongfeng Luo , Meicun Yao , Zhiyong Xie , Hao Li . Utilizing bivalent aptamers as first DNA agonist to activate RTKs heterodimer of different families. Chinese Chemical Letters, 2025, 36(1): 109839-. doi: 10.1016/j.cclet.2024.109839
4. [4]
  Jie ZHANG , Xin LIU , Zhixin LI , Yuting PEI , Yuqi YANG , Huimin LI , Zhiqiang LIU . Assembling a luminescence silencing system based on post-synthetic modification strategy: A highly sensitive and selective turn-on metal-organic framework probe for ascorbic acid detection. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 823-833. doi: 10.11862/CJIC.20230310
5. [5]
  Shicheng Dong , Jun Zhu . Could π-aromaticity cross an unsaturated system to a fully saturated one?. Chinese Chemical Letters, 2024, 35(6): 109214-. doi: 10.1016/j.cclet.2023.109214
6. [6]
  Shehla Khalid , Muhammad Bilal , Nasir Rasool , Muhammad Imran . Photochemical reactions as synthetic tool for pharmaceutical industries. Chinese Chemical Letters, 2024, 35(9): 109498-. doi: 10.1016/j.cclet.2024.109498
7. [7]
  Jiayu Xu , Meng Li , Baoxia Dong , Ligang Feng . Fully fluorinated hybrid zeolite imidazole/Prussian blue analogs with combined advantages for efficient oxygen evolution reaction. Chinese Chemical Letters, 2024, 35(6): 108798-. doi: 10.1016/j.cclet.2023.108798
8. [8]
  Xue-Zhi Wang , Yi-Tong Liu , Chuang-Wei Zhou , Bei Wang , Dong Luo , Mo Xie , Meng-Ying Sun , Yong-Liang Huang , Jie Luo , Yan Wu , Shuixing Zhang , Xiao-Ping Zhou , Dan Li . Amplified circularly polarized luminescence of chiral metal-organic frameworks via post-synthetic installing pillars. Chinese Chemical Letters, 2024, 35(10): 109380-. doi: 10.1016/j.cclet.2023.109380
9. [9]
  Hao Wang , Meng-Qi Pan , Ya-Fei Wang , Chao Chen , Jian Xu , Yuan-Yuan Gao , Chuan-Song Qi , Wei Li , Xian-He Bu . Post-synthetic modifications of MOFs by different bolt ligands for controllable release of cargoes. Chinese Chemical Letters, 2024, 35(10): 109581-. doi: 10.1016/j.cclet.2024.109581
10. [10]
  Qiang Wu , Baofeng Wang . Exploring synthetic strategy for stabilizing nickel-rich layered oxide cathodes through structural design. Chinese Chemical Letters, 2024, 35(12): 110089-. doi: 10.1016/j.cclet.2024.110089
11. [11]
  Junyi Yu , Yin Cheng , Anhong Cai , Xianfeng Huang , Qingrui Zhang . Synthetic Cu(Ⅲ) from copper plating wastewater for onsite decomplexation of Cu(Ⅱ)- and Ni(Ⅱ)-organic complexes. Chinese Chemical Letters, 2025, 36(2): 110549-. doi: 10.1016/j.cclet.2024.110549
12. [12]
  Biao Fang , Runwei Mo . PVDF-based solid-state battery. Chinese Journal of Structural Chemistry, 2024, 43(8): 100347-100347. doi: 10.1016/j.cjsc.2024.100347
13. [13]
  Wen LUO , Lin JIN , Palanisamy Kannan , Jinle HOU , Peng HUO , Jinzhong YAO , Peng WANG . Preparation of high-performance supercapacitor based on bimetallic high nuclearity titanium-oxo-cluster based electrodes. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 782-790. doi: 10.11862/CJIC.20230418
14. [14]
  Meihui Liu , Xinyuan Zhou , Xiao Li , Zhenjie Xue , Tie Wang . Pushing the frontiers: Chip-based detection based on micro- and nano-structures. Chinese Chemical Letters, 2024, 35(4): 108875-. doi: 10.1016/j.cclet.2023.108875
15. [15]
  Haixian Ren , Yuting Du , Xiaojing Yang , Fangjun Huo , Le Zhang , Caixia Yin . Development of ESIPT-based specific fluorescent probes for bioactive species based on the protection-deprotection of the hydroxyl. Chinese Chemical Letters, 2025, 36(2): 109867-. doi: 10.1016/j.cclet.2024.109867
16. [16]
  Ning LI , Siyu DU , Xueyi WANG , Hui YANG , Tao ZHOU , Zhimin GUAN , Peng FEI , Hongfang MA , Shang JIANG . Preparation and efficient catalysis for olefins epoxidation of a polyoxovanadate-based hybrid. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 799-808. doi: 10.11862/CJIC.20230372
17. [17]
  Yang Qin , Jiangtian Li , Xuehao Zhang , Kaixuan Wan , Heao Zhang , Feiyang Huang , Limei Wang , Hongxun Wang , Longjie Li , Xianjin Xiao . Toeless and reversible DNA strand displacement based on Hoogsteen-bond triplex. Chinese Chemical Letters, 2024, 35(5): 108826-. doi: 10.1016/j.cclet.2023.108826
18. [18]
  Tiankai Sun , Hui Min , Zongsu Han , Liang Wang , Peng Cheng , Wei Shi . Rapid detection of nanoplastic particles by a luminescent Tb-based coordination polymer. Chinese Chemical Letters, 2024, 35(5): 108718-. doi: 10.1016/j.cclet.2023.108718
19. [19]
  Mengjun Sun , Zhi Wang , Jvhui Jiang , Xiaobing Wang , Chuang Yu . Gelation mechanisms of gel polymer electrolytes for zinc-based batteries. Chinese Chemical Letters, 2024, 35(5): 109393-. doi: 10.1016/j.cclet.2023.109393
20. [20]
  Chen Lu , Zefeng Yu , Jing Cao . Advancement in porphyrin/phthalocyanine compounds-based perovskite solar cells. Chinese Journal of Structural Chemistry, 2024, 43(3): 100240-100240. doi: 10.1016/j.cjsc.2024.100240

Get Citation

PDF

XML

Metrics

PDF Downloads(4)
Abstract views(681)
HTML views(11)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142