Citation: Lei Zuhai, Zeng Zhenhua, Qian Xuhong, Yang Youjun. A novel chromogenic and fluorogenic scaffold for detection of oxidative radicals[J]. Chinese Chemical Letters, ;2017, 28(10): 2001-2004. doi: 10.1016/j.cclet.2017.09.023 shu

A novel chromogenic and fluorogenic scaffold for detection of oxidative radicals

Lei Zuhai ^b ,
Zeng Zhenhua ^b ,
Qian Xuhong ^a,b ,
Yang Youjun ^a,b,,

a.
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
b.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: Yang Youjun, youjunyang@ecust.edu.cn
Received Date: 7 July 2017
Revised Date: 6 September 2017
Accepted Date: 7 September 2017
Available Online: 8 October 2017

Figures(5)

Radical detection has attracted significant attention recently. Here we have developed a scaffold through covalent assembly principle (OR570), which could facile applications in detection of oxidative radicals. The primary advantage of the assembly type probe lies at the turn-on fluorescence signal from a zero background and hence high fluorescence turn-on ratio for sensitive detection of weak signal.
- Radicals,
- Fluorescent probe,
- Covalent assembly,
- Nitrogen dioxide,
- Fluorogenic
1. [1]
  I. Fridovich, Ann. Rev. Biochem. 44(1975) 147-159. doi: 10.1146/annurev.bi.44.070175.001051
2. [2]
  D.R. Blake, R.E. Allen, J. Lunec, Br. Med. Bull. 43(1987) 371-385. doi: 10.1093/oxfordjournals.bmb.a072188
3. [3]
  P. Pacher, J.S. Beckman, L. Liaudet, Physiol. Rev. 87(2007) 315-424. doi: 10.1152/physrev.00029.2006
4. [4]
  L.A. Pham-Huy, H. He, C. Pham-Huy, Int. J. Biomed. Sci. 4(2008) 89-96.
5. [5]
  B.N. Ames, R. Cathcart, E. Schwiers, P. Hochstein, Proc. Natl. Acad. Sci. U. S. A. 78(1981) 6858-6862. doi: 10.1073/pnas.78.11.6858
6. [6]
  C. Michiels, M. Raes, O. Toussaint, J. Remacle, Free Radic. Biol. Med. 17(1994) 235-248. doi: 10.1016/0891-5849(94)90079-5
7. [7]
  N. Smirnoff, Curr. Opin. Plant Biol. 3(2000) 229-235. doi: 10.1016/S1369-5266(00)00069-8
8. [8]
  A. Chan, Can. J. Physiol. Pharm. 71(1993) 725-731. doi: 10.1139/y93-109
9. [9]
  C.H. Foyer, G. Noctor, Plant Physiol. 155(2011) 2-18. doi: 10.1104/pp.110.167569
10. [10]
  C. Bogdan, M. Rollinghoff, A. Diefenbach, Curr. Opin. Immunol. 12(2000) 64-76. doi: 10.1016/S0952-7915(99)00052-7
11. [11]
  F.C. Fang, Nat. Rev. Microb. 2(2004) 820-832. doi: 10.1038/nrmicro1004
12. [12]
  P. Wardman, Free Radic. Biol. Med. 43(2007) 995-1022. doi: 10.1016/j.freeradbiomed.2007.06.026
13. [13]
  K. Yamada, F. Mito, Y. Matsuoka, et al., Nat. Chem. Biol. 12(2016) 608-613. doi: 10.1038/nchembio.2105
14. [14]
  A.O.M. Barzegar, A. Zavras, C.H. Schiesser, et al., Org. Biomol. Chem. 14(2016) 2272-2281. doi: 10.1039/C5OB02441B
15. [15]
  R. Huber, T. Fiebig, H.A. Wagenknecht, Chem. Commun. 15(2003) 1878-1879.
16. [16]
  N.B. Yapici, S. Jockusch, A. Moscatelli, et al., Org. Lett. 14(2012) 50-53. doi: 10.1021/ol202816m
17. [17]
  L. Meng, Y. Wu, T. Yi, Chem. Commun. 50(2014) 4843-4845. doi: 10.1039/C4CC00975D
18. [18]
  F. Si, Y. Liu, K. Yan, et al., Chem. Commun. 51(2015) 7931-7934. doi: 10.1039/C5CC01075F
19. [19]
  K. Kundu, S.F. Knight, N. Willett, et al., Angew. Chem. Int. Ed. 48(2009) 299-303. doi: 10.1002/anie.v48:2
20. [20]
  K. Setsukinai, Y. Urano, K. Kakinuma, et al., J. Biol. Chem. 278(2003) 3170-3175. doi: 10.1074/jbc.M209264200
21. [21]
  Q. Zhang, Z. Zhu, Y. Zheng, et al., J. Am. Chem. Soc. 134(2012) 18479-18482. doi: 10.1021/ja305046u
22. [22]
  Z. Lei, Y. Yang, J. Am. Chem. Soc. 136(2014) 6594-6597. doi: 10.1021/ja502945q
23. [23]
  L. Song, Z. Lei, B. Zhang, et al., Anal. Methods 6(2014) 7597-7600. doi: 10.1039/C4AY01729C
24. [24]
  Z. Zhang, B. Zhang, X. Qian, et al., Anal. Chem. 86(2014) 11919-11924. doi: 10.1021/ac503900w
25. [25]
  Y. Yang, S.K. Seidlits, M.M. Adames, et al., J. Am. Chem. Soc. 132(2010) 13114-13116. doi: 10.1021/ja1040013
26. [26]
  Y. Shen, Q. Zhang, X. Qian, et al., Anal. Chem. 87(2015) 1274-1280. doi: 10.1021/ac5039779
1. [1]
  Chengcheng Zhang , Zhe Wu , Ningning Jiang , Yi Song , Weina Geng , Hongmei Liu , Ming Jin , Shuxiang Wang , Jinchao Zhang , Yutao Yang . A fluorescent probe regulated by trifluoromethyl and nitrogen-containing heterocycles for monitoring biothiol fluctuations in the brains of mice with schizophrenia. Chinese Chemical Letters, 2026, 37(1): 111476-. doi: 10.1016/j.cclet.2025.111476
2. [2]
  Pengfei Li , Chulin Qu , Fan Wu , Hu Gao , Chengyan Zhao , Yue Zhao , Zhen Shen . Robust free-base and metalated corrole radicals with reduction-induced emission. Chinese Chemical Letters, 2025, 36(2): 110292-. doi: 10.1016/j.cclet.2024.110292
3. [3]
  Yudi Cheng , Xiao Wang , Jiao Chen , Zihan Zhang , Jiadong Ou , Mengyao She , Fulin Chen , Jianli Li . A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H₂S and its applications in living system. Chinese Chemical Letters, 2024, 35(5): 109156-. doi: 10.1016/j.cclet.2023.109156
4. [4]
  Chuan-Zhi Ni , Ruo-Ming Li , Fang-Qi Zhang , Qu-Ao-Wei Li , Yuan-Yuan Zhu , Jie Zeng , Shuang-Xi Gu . A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells. Chinese Chemical Letters, 2024, 35(10): 109862-. doi: 10.1016/j.cclet.2024.109862
5. [5]
  Tao Liu , Xuwei Han , Xueyi Sun , Weijie Zhang , Ke Gao , Runan Min , Yuting Tian , Caixia Yin . An activated fluorescent probe to monitor NO fluctuation in Parkinson’s disease. Chinese Chemical Letters, 2025, 36(3): 110170-. doi: 10.1016/j.cclet.2024.110170
6. [6]
  Qian Pang , Fangjun Huo , Yongkang Yue , Caixia Yin . ONOO⁻ and viscosity dual-response fluorescent probe for arthritis imaging in vivo. Chinese Chemical Letters, 2025, 36(9): 110713-. doi: 10.1016/j.cclet.2024.110713
7. [7]
  Chao Liu , Chao Jia , Shi-Xian Gan , Qiao-Yan Qi , Guo-Fang Jiang , Xin Zhao . A luminescent one-dimensional covalent organic framework for organic arsenic sensing in water. Chinese Chemical Letters, 2024, 35(11): 109750-. doi: 10.1016/j.cclet.2024.109750
8. [8]
  Huamei Zhang , Jingjing Liu , Mingyue Li , Shida Ma , Xucong Zhou , Aixia Meng , Weina Han , Jin Zhou . Imaging polarity changes in pneumonia and lung cancer using a lipid droplet-targeted near-infrared fluorescent probe. Chinese Chemical Letters, 2024, 35(12): 110020-. doi: 10.1016/j.cclet.2024.110020
9. [9]
  Fan Zheng , Runsha Xiao , Shuai Huang , Zhikang Chen , Chen Lai , Anyao Bi , Heying Yao , Xueping Feng , Zihua Chen , Wenbin Zeng . Accurate visualization colorectal cancer by monitoring viscosity variations with a novel mitochondria-targeted fluorescent probe. Chinese Chemical Letters, 2025, 36(2): 109876-. doi: 10.1016/j.cclet.2024.109876
10. [10]
  Zhixiao Xiong , Shanni Qiu , Yuyu Wang , Houna Duan , Yi Xiao , Yufang Xu , Weiping Zhu , Xuhong Qian . Photocalibrated NO release from the zinc ion fluorescent probe based on naphthalimide and its application in living cells. Chinese Chemical Letters, 2025, 36(4): 110002-. doi: 10.1016/j.cclet.2024.110002
11. [11]
  Jiayu Zeng , Minhui Liu , Ting Yang , Jia Huang , Songjiao Li , Wanting Zhang , Dan Cheng , Longwei He , Jia Zhou . Two-dimensional design strategy to construct smart dual-responsive fluorescent probe for the precise tracking of ischemic stroke. Chinese Chemical Letters, 2025, 36(5): 110166-. doi: 10.1016/j.cclet.2024.110166
12. [12]
  Xianzhu Luo , Feifei Yu , Rui Wang , Tian Su , Pan Luo , Pengfei Wen , Fabiao Yu . A near-infrared two-photon fluorescent probe for the detection of HClO in inflammatory and tumor-bearing mice. Chinese Chemical Letters, 2025, 36(7): 110531-. doi: 10.1016/j.cclet.2024.110531
13. [13]
  Xinyi Zhao , Yuai Duan , Zihan Liu , Hua Geng , Yaping Li , Zhongfeng Li , Tianyu Han . Mapping sweat pores for biometric identification based on a donor-acceptor hydrophilic fluorescent probe. Chinese Chemical Letters, 2025, 36(8): 110617-. doi: 10.1016/j.cclet.2024.110617
14. [14]
  Mengyu Cao , Yiyan Yin , Jingyi Qin , Jin Ouyang , Na Na . Unconventional application of a fluorescent probe for MS-based detection of multiple sulfur species in ferroptosis. Chinese Chemical Letters, 2026, 37(1): 111260-. doi: 10.1016/j.cclet.2025.111260
15. [15]
  Meitong Wu , Ke Wu , Shumin Feng , Li Xu , Mi Lei , Jianmei Chen , Shuang Li , Mian Qin , Dahui Liu , Guoqiang Feng . A NIR and ratiometric fluorescent probe for quantitative detection of SO₂ derivatives in Chinese medicinal materials and bioimaging in vivo. Chinese Chemical Letters, 2026, 37(1): 110979-. doi: 10.1016/j.cclet.2025.110979
16. [16]
  Chuanfeng Fan , Jian Gao , Yingkai Gao , Xintong Yang , Gaoning Li , Xiaochun Wang , Fei Li , Jin Zhou , Haifeng Yu , Yi Huang , Jin Chen , Yingying Shan , Li Chen . A non-peptide-based chymotrypsin-targeted long-wavelength emission fluorescent probe with large Stokes shift and its application in bioimaging. Chinese Chemical Letters, 2024, 35(10): 109838-. doi: 10.1016/j.cclet.2024.109838
17. [17]
  Lei Shen , Hongmei Liu , Ming Jin , Jinchao Zhang , Caixia Yin , Shuxiang Wang , Yutao Yang . “Three-in-one” strategy of trifluoromethyl regulated blood-brain barrier permeable fluorescent probe for peroxynitrite and antiepileptic evaluation of edaravone. Chinese Chemical Letters, 2024, 35(10): 109572-. doi: 10.1016/j.cclet.2024.109572
18. [18]
  Han-Min Wang , Yan-Chen Li , Lu-Lu Sun , Ming-Ye Tang , Jia Liu , Jiahao Cai , Lei Dong , Jia Li , Yi Zang , Hai-Hao Han , Xiao-Peng He . Protein-encapsulated long-wavelength fluorescent probe hybrid for imaging lipid droplets in living cells and mice with non-alcoholic fatty liver. Chinese Chemical Letters, 2024, 35(11): 109603-. doi: 10.1016/j.cclet.2024.109603
19. [19]
  Wenping Dong , Mo Ma , Jingkang Li , Lanlan Xu , Dejiang Gao , Pinyi Ma , Daqian Song . Near-infrared fluorescent probe with large Stokes shift and long emission wavelength for rapid diagnosis of lung cancer via aerosol inhalation delivery. Chinese Chemical Letters, 2025, 36(5): 110147-. doi: 10.1016/j.cclet.2024.110147
20. [20]
  Lei Li , Guang Yang , Tianbai Xiong , Tingzhu Duan , Jia Wang , Xin Wang . Metal-free click polymerization of thiols and chalcone-derived internal olefins in air to prepare functional clusteroluminescent polythioethers for dual-response fluorescent probe. Chinese Chemical Letters, 2025, 36(11): 111374-. doi: 10.1016/j.cclet.2025.111374

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(1708)
HTML views(78)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142