Citation: Tang Ying, Meng Zi-Hui, Xu Hong, Wu Chang-Feng. Semiconducting polymer dots with photosensitizer loading and peptide modification for enhanced cell penetration and photodynamic effect[J]. Chinese Chemical Letters, ;2017, 28(11): 2164-2168. doi: 10.1016/j.cclet.2017.08.015 shu

Semiconducting polymer dots with photosensitizer loading and peptide modification for enhanced cell penetration and photodynamic effect

Tang Ying ^a,1 ,
Meng Zi-Hui ^b,1 ,
Xu Hong ^a,, ,
Wu Chang-Feng ^c,,

a.
Department of Gastroenterology, The First Hospital of Jilin University, Changchun 130021, China
b.
Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China
c.
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 510855, China

Corresponding author: Xu Hong, chxuhong@163.com Wu Chang-Feng, wucf@sustc.edu.cn; changfengwu76@gmail.com

Received Date: 21 June 2017
Revised Date: 10 August 2017
Accepted Date: 13 August 2017
Available Online: 18 November 2017

Figures(4)

This letter describes semiconducting polymer dots (Pdots) doped with a photosensitizer and modified with a cell penetrating peptide for photodynamic therapy (PDT). The resulting Pdots exhibited efficient singlet oxygen (¹O₂) generation mediated by intraparticle energy transfer. Experimental results indicated that the peptide-coated Pdots could promote the cellular uptake and increase the penetration efficiency in vitro, and effectively suppressed tumor growth and enhanced the photodynamic effect in vivo. Our results demonstrate that Pdots with photosensitizer loading and peptide modification hold great promise for cancer therapy.
- Photodynamic therapy,
- Cell penetrating peptides,
- Polymer dots,
- Photosensitizer,
- Cancer
1. [1]
  D.E. Dolmans, D. Fukumura, R.K. Jain, Nat. Rev. Cancer 3(2003) 380-387. doi: 10.1038/nrc1071
2. [2]
  M. Triesscheijn, P. Baas, J.H. Schellens, F.A. Stewart, Oncologist 11(2006) 1034-1044. doi: 10.1634/theoncologist.11-9-1034
3. [3]
  L.L. Rui, H.L. Cao, Y.D. Xue, et al., Chin. Chem. Lett. 27(2016) 1412-1420. doi: 10.1016/j.cclet.2016.07.011
4. [4]
  T.J. Dougherty, C.J. Gomer, B.W. Henderson, et al., J. Natl. Cancer Inst. 90(1998) 889-905. doi: 10.1093/jnci/90.12.889
5. [5]
  M. Niedre, M.S. Patterson, B.C. Wilson, Photochem. Photobiol. 75(2002) 382-391. doi: 10.1562/0031-8655(2002)0750382DNILDO2.0.CO2
6. [6]
  A.P. Castano, P. Mroz, M.R. Hamblin, Nat. Rev. Cancer 6(2006) 535-545. doi: 10.1038/nrc1894
7. [7]
  K. Kostovic, Z. Pastar, R. Ceovic, et al., Coll. Antropol. 36(2012) 1477-1481.
8. [8]
  N. Yavari, S. Andersson-Engels, U. Segersten, P.U. Malmstrom, Can. J. Urol. 18(2011) 5778-5786.
9. [9]
  R. Allison, K. Moghissi, G. Downie, K. Dixon, Photodiagn. Photodyn. Ther. 8(2011) 231-239. doi: 10.1016/j.pdpdt.2011.03.342
10. [10]
  B. Green, A.R. Cobb, C. Hopper, Br. J. Oral Maxillofac. Surg. 51(2013) 283-287. doi: 10.1016/j.bjoms.2012.11.011
11. [11]
  J.P. Wei, X.L. Chen, X.Y. Wang, et al., Chin. Chem. Lett. (2017), doi:http://dx.doi.org/10.1016/j.cclet.2017.01.007.
12. [12]
  Y. Liu, Y. Liu, W. Bu, et al., Angew. Chem. Int. Ed. 54(2015) 8105-8109. doi: 10.1002/anie.201500478
13. [13]
  J. Rieffel, F. Chen, J. Kim, et al., Adv. Mater. 27(2015) 1785-1790. doi: 10.1002/adma.201404739
14. [14]
  C. Wang, L. Cheng, Y.M. Liu, et al., Adv. Funct. Mater. 23(2013) 3077-3086. doi: 10.1002/adfm.v23.24
15. [15]
  H.D. Cui, D.H. Hu, J.N. Zhang, et al., Chin. Chem. Lett. (2017), doi:http://dx.doi.org/10.1016/j.cclet.2016.12.038.
16. [16]
  F. Chen, H. Hong, S. Goel, et al., ACS Nano 9(2015) 3926-3934. doi: 10.1021/nn507241v
17. [17]
  Z.X. Zhao, Y.Z. Huang, S.G. Shi, et al., Nanotechnology 25(2014) 285701. doi: 10.1088/0957-4484/25/28/285701
18. [18]
  C.Y. Hsu, C.W. Chen, H.P. Yu, Y.F. Lin, P.S. Lai, Biomaterials 34(2013) 1204-1212. doi: 10.1016/j.biomaterials.2012.08.044
19. [19]
  J.M. Tsay, M. Trzoss, L. Shi, et al., J. Am. Chem. Soc. 129(2007) 6865-6871. doi: 10.1021/ja070713i
20. [20]
  J. Pecher, S. Mecking, Chem. Rev 110(2010) 6260-6279. doi: 10.1021/cr100132y
21. [21]
  A. Kaeser, A.P. Schenning, Adv. Mater. 22(2010) 2985-2997. doi: 10.1002/adma.v22:28
22. [22]
  D. Tuncel, H.V. Demir, Nanoscale 2(2010) 484-494. doi: 10.1039/b9nr00374f
23. [23]
  C. Wu, D.T. Chiu, Angew. Chem. Int. Ed. 52(2013) 3086-3109. doi: 10.1002/anie.201205133
24. [24]
  S. Li, K. Chang, K. Sun, et al., ACS Appl. Mater. Interfaces 8(2016) 3624-3634. doi: 10.1021/acsami.5b07995
25. [25]
  C. Wu, B. Bull, C. Szymanski, K. Christensen, J. McNeill, ACS Nano 2(2008) 2415-2423. doi: 10.1021/nn800590n
26. [26]
  T. Feng, X. Ai, G. An, P. Yang, Y. Zhao, ACS Nano 10(2016) 4410-4420. doi: 10.1021/acsnano.6b00043
27. [27]
  L. Feng, J. Zhu, Z. Wang, ACS Appl. Mater. Interfaces 8(2016) 19364-19370. doi: 10.1021/acsami.6b06642
28. [28]
  L. Zhang, F. Liu, G. Li, Y. Zhou, Y. Yang, J. Pharm. Sci. 104(2015) 4185-4196. doi: 10.1002/jps.24649
29. [29]
  X. Ma, S. Sreejith, Y. Zhao, ACS Appl. Mater. Interfaces 5(2013) 12860-12868. doi: 10.1021/am404578h
30. [30]
  Y. Tang, H. Chen, K. Chang, et al., ACS Appl. Mater. Interfaces 9(2017) 3419-3431. doi: 10.1021/acsami.6b14325
31. [31]
  S. Chemburu, T.S. Corbitt, L.K. Ista, et al., Langmuir 24(2008) 11053-11062. doi: 10.1021/la8016547
32. [32]
  J.L. Grimland, C.F. Wu, R.R. Ramoutar, J.L. Brumaghim, J. McNeill, Nanoscale 3(2011) 1451-1455. doi: 10.1039/c0nr00834f
33. [33]
  H.F. Shi, X. Ma, Q. Zhao, et al., Adv. Funct. Mater. 24(2014) 4823-4830. doi: 10.1002/adfm.v24.30
34. [34]
  R.W. Redmond, J.N. Gamlin, Photochem. Photobiol. 70(1999) 391-475. doi: 10.1111/php.1999.70.issue-4
35. [35]
  A. Komin, L.M. Russell, K.A. Hristova, P.C. Searson, Adv. Drug Deliv. Rev.110-111(2016) 52-64.
1. [1]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
2. [2]
  Zhe Li , Ping-Zhao Liang , Li Xu , Fei-Yu Yang , Tian-Bing Ren , Lin Yuan , Xia Yin , Xiao-Bing Zhang . Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy. Chinese Chemical Letters, 2024, 35(8): 109190-. doi: 10.1016/j.cclet.2023.109190
3. [3]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133
4. [4]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
5. [5]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
6. [6]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
7. [7]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882
8. [8]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
9. [9]
  Xinyue Lan , Junguang Liang , Churan Wen , Xiaolong Quan , Huimin Lin , Qinqin Xu , Peixian Chen , Guangyu Yao , Dan Zhou , Meng Yu . Photo-manipulated polyunsaturated fatty acid-doped liposomal hydrogel for flexible photoimmunotherapy. Chinese Chemical Letters, 2024, 35(4): 108616-. doi: 10.1016/j.cclet.2023.108616
10. [10]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
11. [11]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969
12. [12]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
13. [13]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
14. [14]
  Huijiao Fu , Peiqin Liang , Qianwen Chen , Yan Wang , Guang Li , Xuzi Cai , Shengtao Wang , Kun Chen , Shengying Shi , Zhiqiang Yu , Xuefeng Wang . COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer: An allicin-based nanomedicine approach. Chinese Chemical Letters, 2024, 35(8): 109241-. doi: 10.1016/j.cclet.2023.109241
15. [15]
  Yihan Zhou , Duo Gao , Yaying Wang , Li Liang , Qingyu Zhang , Wenwen Han , Jie Wang , Chunliu Zhu , Xinxin Zhang , Yong Gan . Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108967-. doi: 10.1016/j.cclet.2023.108967
16. [16]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
17. [17]
  Lin Li , Bingjun Sun , Jin Sun , Lin Chen , Zhonggui He . Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109538-. doi: 10.1016/j.cclet.2024.109538
18. [18]
  Yang Liu , Yan Liu , Kaiyin Yang , Zhiruo Zhang , Wenbo Zhang , Bingyou Yang , Hua Li , Lixia Chen . A selective HK2 degrader suppresses SW480 cancer cell growth by degrading HK2. Chinese Chemical Letters, 2024, 35(8): 109264-. doi: 10.1016/j.cclet.2023.109264
19. [19]
  Jing Chen , Peisi Xie , Pengfei Wu , Yu He , Zian Lin , Zongwei Cai . MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids. Chinese Chemical Letters, 2024, 35(4): 108895-. doi: 10.1016/j.cclet.2023.108895
20. [20]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(640)
HTML views(23)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142