Citation: Yang Fu, Wang Chao, Wang Lu, Ye Zhi-Wei, Song Xin-Bo, Xiao Yi. Hoechst-naphthalimide dyad with dual emissions as specific and ratiometric sensor for nucleus DNA damage[J]. Chinese Chemical Letters, ;2017, 28(10): 2019-2022. doi: 10.1016/j.cclet.2017.07.030 shu

Hoechst-naphthalimide dyad with dual emissions as specific and ratiometric sensor for nucleus DNA damage

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, China

Corresponding author: Xiao Yi, xiaoyi@dlut.edu.cn

Received Date: 10 April 2017
Revised Date: 17 May 2017
Accepted Date: 30 July 2017
Available Online: 4 October 2017

Figures(4)

A ratiometric fluorescent sensor (Hoe-NI) was developed by connecting a nucleus targeted Hoechst unit to a naphthalimide dye via "click chemistry". The sensor achieves high specific nucleus labeling with wash-free staining method in various kinds of living cells. The fluorescence ratio of the two emission bands (450 nm for Hoechst and 505 nm for naphthalimide) is changed sensitively to the variation of DNA concentrations, which provides the quantitative information in the processes of DNA damage induced by hydroxyl radicals and antitumor drug. Therefore, Hoe-NI is a recommendable sensor for the monitoring of nuclear DNA damage that reveals the health status of cells.
- DNA damage,
- Ratiometric sensor,
- Fluorescenct imaging,
- Nucleus labeling,
- Naphthalimide
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