Citation: Kong Linlin, Amstad Esther, Hai Mingtan, Ke Xinyou, Chen Dong, Zhao Chun-Xia, Weitz David A.. Biocompatible microcapsules with a water core templated from single emulsions[J]. Chinese Chemical Letters, ;2017, 28(9): 1897-1900. doi: 10.1016/j.cclet.2017.07.017 shu

Biocompatible microcapsules with a water core templated from single emulsions

Kong Linlin ^a,b ,
Amstad Esther ^c ,
Hai Mingtan ^c ,
Ke Xinyou ^c ,
Chen Dong ^a,b,c,, ,
Zhao Chun-Xia ^c,4,, ,
Weitz David A. ^c,,

a.
Institute of Process Equipment, College of Energy Engineering, Zhejiang University, Hangzhou 310027, China
b.
State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, China
c.
John A. Paulson School of Engineer and Applied Science, Harvard University, Cambridge, MA 02138, USA
d.
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia

Corresponding author: Chen Dong, chen_dong@zju.edu.cn; 1142182861@qq.com Zhao Chun-Xia, z.chunxia@uq.edu.au Weitz David A., weitz@seas.harvard.edu
Received Date: 21 April 2017
Revised Date: 15 May 2017
Accepted Date: 14 July 2017
Available Online: 20 September 2017

Figures(5)

Biocompatible microcapsules with a water core are widely used to encapsulate hydrophilic actives. Here, a facile method to fabricate monodisperse biocompatible microcapsules with a water core in large quantity is reported. Microfluidic technology is utilized to emulsify the inner aqueous phase containing the shell polymer into monodisperse drops in the outer oil phase. As the cosolvent in the inner aqueous phase diffuses into the outer oil phase, the solubility of the shell polymer decreases, which eventually precipitates. Since the shell polymer, shellac, contains both hydrophilic and hydrophobic groups, it tends to wet both the inner aqueous phase and the outer oil phase, thus forming a solid shell at the periphery of the drop. We show that the diffusion rate of hydrophilic molecules encapsulated in the water core decreases as their molecular weight increases and the property of the microcapsules could further be modified by polyelectrolyte multilayer coating. These microcapsules are fabricated using FDA-approved polymer and non-toxic solvents and are of great use in drugs, cosmetics and foods.
- Microcapsule,
- Microfluidic,
- Biocompatible,
- Single emulsion,
- Hydrophilic actives
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沈阳化工大学材料科学与工程学院沈阳 110142