Citation: Ren Hui-Hui, Zhao Hui-Yu, Cui Yang, Ao Xiang, Li Ai-Ling, Zhang Zhong-Min, Qiu Dong. Poly(1, 8-octanediol citrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration[J]. Chinese Chemical Letters, ;2017, 28(11): 2116-2120. doi: 10.1016/j.cclet.2017.07.014 shu

Poly(1, 8-octanediol citrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration

Ren Hui-Hui ^a,b,1 ,
Zhao Hui-Yu ^c,1 ,
Cui Yang ^a,b ,
Ao Xiang ^c ,
Li Ai-Ling ^a ,
Zhang Zhong-Min ^c,, ,
Qiu Dong ^a,b,,

a.
Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b.
University of Chinese Academy of Sciences, Beijing 100190, China
c.
Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510665, China

Corresponding author: Zhang Zhong-Min, nfzzm@163.com Qiu Dong, dqiu@iccas.ac.cn

^**

Received Date: 27 April 2017
Revised Date: 9 June 2017
Accepted Date: 12 July 2017
Available Online: 17 November 2017

Figures(4)

Poly(1, 8-octanediol-co-citrate) (POC) represents a new promising biocompatible and biodegradable polyester that has been extensively investigated for soft tissue engineering. However, the poor mechanical performance and poor bioactivity limit its application in bone regeneration. In this study, a series of POC/bioactive glasses (BG) composites were developed using 45S5 Bioglass^® and a phytic acidderived bioactive glass (referred as PSC). The results indicated that calcium in BG could enhance the crosslinking of the POC/BG composites by forming calcium dicarboxylate bridges and thus improve their mechanical performances. When PSC were used, the composites exhibited significantly better mechanical properties compared to composites with 45S5 Bioglass^®. For example, by incorporating 70 wt% PSC, the compressive strength of POC/PSC composites could be improved to approximately 50 MPa and modulus 1.3±0.1 GPa. Furthermore, all these POC/PSC composites showed good in vitro bioactivity and cellular biocompatibility. Histology results in femoral condyle defects of Sprague-Dawley rats indicated that the POC/PSC samples integrated well with surrounding tissues and stimulated bone regeneration. The improved mechanical properties and bioactivity of POC/PSC composites make them promising for potential application in bone regeneration.
- Bioactive glasses,
- Poly(1, 8-octanediol-co-citrate),
- Composites,
- Mechanical properties,
- Bioactivity
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