Citation: Zhi-Yao He, Jin Zhao-Hui, Zhan Mei, Qin Zhou, Li Zhi, Xu Ting. Advances in quantum dot-mediated siRNA delivery[J]. Chinese Chemical Letters, ;2017, 28(9): 1851-1856. doi: 10.1016/j.cclet.2017.07.012 shu

Advances in quantum dot-mediated siRNA delivery

Zhi-Yao He ^a ,
Jin Zhao-Hui ^a ,
Zhan Mei ^a ,
Qin Zhou ^a ,
Li Zhi ^b,, ,
Xu Ting ^a,,

a.
Department of Pharmacy, and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China
b.
Department of Gastroenterology, Hospital(T. C. M) Affiliated to Southwest Medical University, Southwest Medical University, Luzhou 646000, China

Corresponding author: Li Zhi, sclzlz2008@126.com Xu Ting, tingx2009@163.com
Received Date: 19 April 2017
Revised Date: 24 May 2017
Accepted Date: 6 July 2017
Available Online: 13 September 2017

Figures(4)

Nano-sized quantum dots (QDs) exhibit uniquely optical properties that are tunable with different sizes and shapes. QDs can emit narrow symmetric bands under a wide excitation range, possess antiphotobleaching stability, and be bio-functionalized on the large surface area. Therefore, QDs are attractive vectors for imaging-guided therapy. Small-interfering RNA (siRNAs)-based therapeutics hold great potential to target a large part of the currently undruggable genes, but overcoming the lipid bilayer to deliver siRNA into cells has remained a major challenge to solve for widespread development of siRNA therapeutics. In this mini-review, we focus on theranostic QD/siRNA assembles for enhancing delivery of siRNA and facilitating evaluation of therapeutic efficacy via imaging of QDs, with special attention to carbonaceous QDs for delivery of siRNA.
- Quantum dot,
- Carbon quantum dot,
- Small-interfering RNA,
- Theranostic,
- Gene delivery,
- Gene therapy
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