Citation: Wu Di, Shen Yuanzhi, Chen Jianhua, Liu Guotao, Chen Haiyan, Yin Jun. Naphthalimide-modified near-infrared cyanine dye with a large stokes shift and its application in bioimaging[J]. Chinese Chemical Letters, ;2017, 28(10): 1979-1982. doi: 10.1016/j.cclet.2017.07.004 shu

Naphthalimide-modified near-infrared cyanine dye with a large stokes shift and its application in bioimaging

Wu Di ^a ,
Shen Yuanzhi ^b ,
Chen Jianhua ^a ,
Liu Guotao ^a ,
Chen Haiyan ^b,, ,
Yin Jun ^a,,

a.
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China
b.
Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China

Corresponding author: Chen Haiyan, chenhaiyan@cpu.edu.cn Yin Jun, yinj@mail.ccnu.edu.cn
Received Date: 27 May 2017
Revised Date: 13 June 2017
Accepted Date: 22 June 2017
Available Online: 8 October 2017

Figures(6)

Developing the novel fluorescent dyes with a larger Stokes shift is still a challenge in the research of fluorescence probes. In this work, a naphthalimide-modified near-infrared cyanine dye with an emission at 785 nm has been synthesized for lysosome-targeting imaging. This fluorescent dye showed a large Stokes shift (up to 165 nm) and favorable lysosome-targeting property, which facilitated it to be a potential candidate for studying of lysosomal functions. The result also indicated that the probe is a promising contrast agent for in vivo imaging in mouse models.
- Cyanine,
- Naphthalimide,
- Near-infrared,
- Stokes shift,
- Bioimaging
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