Citation: Wang Bing, Nie Chenyao, Liu Libing, Lv Fengting, Wang Shu. Selective biocompatibility and responsive imaging property of cationic conjugated polyelectrolyte to cancer cells[J]. Chinese Chemical Letters, ;2017, 28(10): 1975-1978. doi: 10.1016/j.cclet.2017.07.002 shu

Selective biocompatibility and responsive imaging property of cationic conjugated polyelectrolyte to cancer cells

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Corresponding author: Liu Libing, liulibing@iccas.ac.cn Wang Shu, wangshu@iccas.ac.cn
Received Date: 13 May 2017
Revised Date: 7 June 2017
Accepted Date: 3 July 2017
Available Online: 8 October 2017

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Optical imaging, as an important molecular imaging modality, has emerged many attractions in studying the biological or molecular events both in cell level and living subject because of its high resolution and sensitivity, noninvasive manner and low cost. Herein, we bring novel insights into a water-soluble conjugated polyelectlyte by deeply studying its properties in cells. Poly(9, 9-bis (6'-N, N, N-trimethy-lammonium hexyl)fluorene phenylene) (PFP), a good biosensing material, was studied in this paper. The biocompatibility of PFP was investigated in different cells, and cell cycle analysis was carried out to explore the reasons of different biocompatibility of PFP to cells. After irradiation, fluorescence enhancement of blue emission and turn-on of long-wavelength emission of PFP in HepG2 cells was observed, which was first reported as far as we know. The differentiated biocompatibility of PFP and its particular imaging properties in cancer cells can help to guide the application of conjugated polymers in cells and provide a new dimension in designing sensitive and responsive imaging materials.
- Imaging cell,
- Conjugated polymers,
- Fluorescence enhancement,
- Long-wavelength emission,
- Selective biocompatibility
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