Citation: Zhang Kuo, Yang Pei-Pei, Zhang Jing-Ping, Wang Lei, Wang Hao. Recent advances of transformable nanoparticles for theranostics[J]. Chinese Chemical Letters, ;2017, 28(9): 1808-1816. doi: 10.1016/j.cclet.2017.07.001 shu

Recent advances of transformable nanoparticles for theranostics

Zhang Kuo ^a,b ,
Yang Pei-Pei ^b ,
Zhang Jing-Ping ^b,, ,
Wang Lei ^b,, ,
Wang Hao ^b,,

a.
School of Chemistry, Northeast Normal University, Changchun 130024, China
b.
CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology(NCNST), Beijing 100190, China

Author Bio:

Dr. Jingping Zhang, Ph.D, now is a professor of Physical Chemistry, the Dean of School of Chemistry of Northeast NormalUniversity, China. She gother B Sc in Chemistry, M Sc in Physical Chemistry, Doctor's degree (Ph.D.) in Inorganic Chemistry at Northeast Normal University. Currently Dr. Jingping Zhang' researches focus on the design of functional materials, such as lithium-ion battery materials, the mechanism for novel organic reaction, and the simulation of microporous organic molecular crystals
Lei Wang, PhD, is a professor of CAS key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST). He received his B.S. (2002) and M.S. (2005) from Northeast Normal University, China, PhD degree (2008) and one-year postdoc training from Chonbuk National University, Korea. He worked as a Lecture at University of Science and Technology Beijing prior to joining the NCNST. His current interests involve development of supramolecular building blocks and their selfassembly/transformation in physiological condition for biomedical applications
Hao Wang obtained his B.S. and Ph. D fromDepartment of Chemistry at Nankai University in 2000 and 2005, respectively. Afterwards, he moved to Universät Würzburg in Germany as an Alexander von Humboldt (AvH) fellow from 2005-2007. After 4-year training at Department of Molecular and Medical Pharmacology in UCLA from 2007-2010, he started his independent career as a "100 Talents Program of the Chinese Academy of Sciences " professorin 2011 in NationalCenter for Nanoscienceand Technology of China. His research interests are to ⅰ) develop supramolecular assemblies in physiological condition; ⅱ) study their bioeffect and further regulate biological behavior; ⅲ) explore supramolecular assemblies based imaging probes and drug delivery systems. We envision that the combination of modular molecular assembly strategy and modern in vivo molecular diagnostics/therapeutics and in vitro molecular diagnostics represents an important paradigm shift for drug discovery and clinical patient management applications
Corresponding author: Zhang Jing-Ping, zhangjp162@nenu.edu.cn Wang Lei, wanglei@nanoctr.cn Wang Hao, wanghao@nanoctr.cn
Received Date: 24 April 2017
Revised Date: 18 May 2017
Accepted Date: 3 July 2017
Available Online: 8 September 2017

Figures(14)

In recent years, various transformable nanoparticles (NPs) were successfully prepared and widely utilized for biomedical applications. The sizes, surface charges or morphologies of transformable NPs would affect their behavior in physiological/pathological conditions including circulation, penetration, accumulation and retention etc. The other way round, the NPs could be precisely modulated in the specific physiological/pathological condition for precision theranostics of diseases. Herein, we summarized recent advances of transformable NPs for disease diagnostics and therapy. In this review, the transformation of NPs was divided into three groups including changes in size, surface charge and morphology, which was induced by internal stimuli, such as pH, enzyme, receptor or external stimuli, such as light, temperature etc. Moreover, we focused on the characterization of structural transformation in vivo, as well as the transformation-induced biological effects for theranostics of disease.
- Transformable,
- Nanoparticles,
- Tumor,
- Imaging,
- Therapy
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沈阳化工大学材料科学与工程学院沈阳 110142