Citation: Zhao Hongzhi, Li Jiufeng, Ma Xinli, Huo Wenqian, Xu Shunqing, Cai Zongwei. Simultaneous determination of bisphenols, benzophenones and parabens in human urine by using UHPLC-TQMS[J]. Chinese Chemical Letters, ;2018, 29(1): 102-106. doi: 10.1016/j.cclet.2017.06.013 shu

Simultaneous determination of bisphenols, benzophenones and parabens in human urine by using UHPLC-TQMS

Zhao Hongzhi ^a ,
Li Jiufeng ^a ,
Ma Xinli ^a,c ,
Huo Wenqian ^b ,
Xu Shunqing ^b,, ,
Cai Zongwei ^a,,

a.
State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, China
b.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China
c.
School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China

Corresponding author: Xu Shunqing, xust@hust.edu.cn Cai Zongwei, zwcai@hkbu.edu.hk
Received Date: 4 April 2017
Revised Date: 25 April 2017
Accepted Date: 7 June 2017
Available Online: 9 January 2017

Figures(3)

Bisphenols, benzophenones and parabens may alter one or more functions of endocrine system and consequently cause adverse health effects on human. A rapid and sensitive analytical method for the simultaneous determination of six bisphenols, five benzophenones and seven parabens in human urine by using ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry was developed and applied for human urine sample analysis. The eighteen targeted compounds were separated within 11 min. Heated-electrospray ionization was operated with multiple reaction monitoring in negative-ion mode. The limit of detection ranged from 0.01 ng/mL to 0.5 ng/mL. Seven isotope-labeled internal standards were used in the quantitative analysis. After the method was validated for sensitivity, linearity, precision, accuracy and matrix effect, it was applied for the analysis of human urine samples to evaluate the profiles of human exposure. Eight of the targeted analytes were detected in more than 50% urine samples.
- Bisphenols,
- Benzophenones,
- Parabens,
- Liquid chromatography-mass spectrometry,
- Human urine
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