Citation: Zhao Hongzhi, Li Jiufeng, Ma Xinli, Huo Wenqian, Xu Shunqing, Cai Zongwei. Simultaneous determination of bisphenols, benzophenones and parabens in human urine by using UHPLC-TQMS[J]. Chinese Chemical Letters, ;2018, 29(1): 102-106. doi: 10.1016/j.cclet.2017.06.013 shu

Simultaneous determination of bisphenols, benzophenones and parabens in human urine by using UHPLC-TQMS

Zhao Hongzhi ^a ,
Li Jiufeng ^a ,
Ma Xinli ^a,c ,
Huo Wenqian ^b ,
Xu Shunqing ^b,, ,
Cai Zongwei ^a,,

a.
State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, China
b.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China
c.
School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China

Corresponding author: Xu Shunqing, xust@hust.edu.cn Cai Zongwei, zwcai@hkbu.edu.hk
Received Date: 4 April 2017
Revised Date: 25 April 2017
Accepted Date: 7 June 2017
Available Online: 9 January 2017

Figures(3)

Bisphenols, benzophenones and parabens may alter one or more functions of endocrine system and consequently cause adverse health effects on human. A rapid and sensitive analytical method for the simultaneous determination of six bisphenols, five benzophenones and seven parabens in human urine by using ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry was developed and applied for human urine sample analysis. The eighteen targeted compounds were separated within 11 min. Heated-electrospray ionization was operated with multiple reaction monitoring in negative-ion mode. The limit of detection ranged from 0.01 ng/mL to 0.5 ng/mL. Seven isotope-labeled internal standards were used in the quantitative analysis. After the method was validated for sensitivity, linearity, precision, accuracy and matrix effect, it was applied for the analysis of human urine samples to evaluate the profiles of human exposure. Eight of the targeted analytes were detected in more than 50% urine samples.
- Bisphenols,
- Benzophenones,
- Parabens,
- Liquid chromatography-mass spectrometry,
- Human urine
1. [1]
  A. Ponten, E. Zimerson, O. Sorensen, M. Bruze, Contact Dermat. 50(2004) 289-297. doi: 10.1111/cod.2004.50.issue-5
2. [2]
  T. Tillett, Environ. Health Perspect. 120(2012) a437.
3. [3]
  J. Muncke, J. Steroid Biochem. Mol. Biol. 127(2011) 118-127. doi: 10.1016/j.jsbmb.2010.10.004
4. [4]
  M. Rodas, L.A. Portugal, J. Avivar, et al., Talanta 143(2015) 254-262. doi: 10.1016/j.talanta.2015.04.055
5. [5]
  F. Camino-Sánchez, A. Zafra-Gómez, N. Dorival-García, et al., Talanta 150(2016) 415-424. doi: 10.1016/j.talanta.2015.12.031
6. [6]
  F. Tohidi, Z.W. Cai, Environ. Sci. Pollut. Res. 22(2015) 11387-11400. doi: 10.1007/s11356-015-4289-x
7. [7]
  K. Ji, S. Hong, Y. Kho, K. Choi, Environ. Sci. Technol. 47(2013) 8793-8800. doi: 10.1021/es400329t
8. [8]
  L.V. Laing, J. Viana, E.L. Dempster, M. Trznadel, et al., Epigenetics 11(2016) 526-538. doi: 10.1080/15592294.2016.1182272
9. [9]
  S. Lee, X. Liu, S. Takeda, K. Choi, Chemosphere 93(2013) 434-440. doi: 10.1016/j.chemosphere.2013.05.029
10. [10]
  J.M. Braun, Nat. Rev. Endocrinol. 13(2016) 161-173.
11. [11]
  C.C. Kuo, K. Moon, K.A. Thayer, A. Navas-Acien, Curr. Diab. Rep. 13(2013) 831-849. doi: 10.1007/s11892-013-0432-6
12. [12]
  P. Deb, A. Bhan, I. Hussain, et al., Gene 590(2016) 234-243. doi: 10.1016/j.gene.2016.05.009
13. [13]
  A. Zhou, H. Chang, W. Huo, et al., Pediatr. Res. (2017), doi:http://dx.doi.org/10.1038/pr.2017.20. doi: 10.1038/pr.2017.20
14. [14]
  I. Jiménez-Díaz, F. Artacho-Cordón, F. Vela-Soria, et al., Sci. Total Environ. 562(2016) 81-88. doi: 10.1016/j.scitotenv.2016.03.203
15. [15]
  X.Y. Ye, A.M. Bishop, J.A. Reidy, L.L. Needham, A.M. Calafat, Environ. Health Perspect. 114(2006) 1843-1846.
16. [16]
  C.A. Beasley, J. Shaw, Z. Zhao, R.A. Reed, J. Pharm. Biomed. Anal. 37(2005) 559-567. doi: 10.1016/j.jpba.2004.11.021
17. [17]
  N. Morin, H.P.H. Arp, S.E. Hale, Environ. Sci. Technol. 49(2015) 7675-7683. doi: 10.1021/acs.est.5b01307
18. [18]
  T. Ma, Z. Li, Q. Niu, Y. Li, W. Zhou, Electrophoresis 36(2015) 2530-2537. doi: 10.1002/elps.201500004
19. [19]
  Y. Liu, X. H. Xun, J.M. Yi, Y. Xiang, J. Hua, Chin. Chem. Lett. 28(2017) 1093-1098. doi: 10.1016/j.cclet.2016.11.026
20. [20]
  Y.L. Shi, Y.Y. Pan, L.N. Liang, Y.Q. Cai, Chin. Chem. Lett. 26(2015) 1073-1078. doi: 10.1016/j.cclet.2015.05.038
21. [21]
  A. Naccarato, E. Gionfriddo, G. Sindona, A. Tagarelli, J. Chromatogr. A 1338(2014) 164-173. doi: 10.1016/j.chroma.2014.02.089
22. [22]
  F. Vela-Soria, O. Ballesteros, A. Zafra-Gómez, L. Ballesteros, A. Navalón, Talanta 121(2014) 97-104. doi: 10.1016/j.talanta.2013.12.048
23. [23]
  C. Esteve, L. Herrero, B. Gómara, J. Quintanilla-López, Talanta 146(2016) 326-334. doi: 10.1016/j.talanta.2015.08.064
24. [24]
  E. Yamazaki, N. Yamashita, S. Taniyasu, et al., Ecotox. Environ. Safe 122(2015) 565-572. doi: 10.1016/j.ecoenv.2015.09.029
25. [25]
  B.A. Rocha, B.R.B. da Costa, N.C.P. de Albuquerque, et al., Talanta 154(2016) 511-519. doi: 10.1016/j.talanta.2016.03.098
26. [26]
  J.G. Teeguarden, N.C. Twaddle, M.I. Churchwell, et al., Toxicol. Appl. Pharmacol. 288(2015) 131-142. doi: 10.1016/j.taap.2015.01.009
27. [27]
  E.J. Carrasco-Correa, F. Vela-Soria, O. Ballesteros, G. Ramis-Ramos, J.M. Herrero-Martinez, J. Chromatogr. A 1379(2015) 65-73. doi: 10.1016/j.chroma.2014.12.053
28. [28]
  FDA, Guidance for industry: bioanalytical method validation, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER) Center for Veterinary Medicine (CV), 2001, pp. 1-19.
29. [29]
  H. Zhao, L. Xiang, J. Li, et al., Rapid Commun. Mass Spectrom. 30(2016) 1901-1913. doi: 10.1002/rcm.7666
30. [30]
  L. Schlittenbauer, B. Seiwert, T. Reemtsma, Anal. Bioanal. Chem. 408(2016) 1573-1583. doi: 10.1007/s00216-015-9265-2
31. [31]
  T. Kunisue, Q. Wu, S. Tanabe, K.M. Aldous, K. Kannan, Anal. Methods 2(2010) 707-713. doi: 10.1039/b9ay00324j
32. [32]
  S. Yakkundi, H. Mulla, H. Pandya, M.A. Turner, J. McElnay, Bioanalysis 8(2016) 1173-1182. doi: 10.4155/bio-2016-0029
33. [33]
  B. Matuszewski, J. Chromatogr. B 830(2006) 293-300. doi: 10.1016/j.jchromb.2005.11.009
34. [34]
  R.K. Moos, H.M. Koch, J. Angerer, et al., Int. J. Hyg. Environ. Health 218(2015) 666-674. doi: 10.1016/j.ijheh.2015.07.005
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