Citation: Jie Mingsha, Mao Sifeng, Haifang Li, Lin Jin-Ming. Multi-channel microfluidic chip-mass spectrometry platform for cell analysis[J]. Chinese Chemical Letters, ;2017, 28(8): 1625-1630. doi: 10.1016/j.cclet.2017.05.024 shu

Multi-channel microfluidic chip-mass spectrometry platform for cell analysis

a.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China
b.
Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China

Corresponding author: Lin Jin-Ming, jmlin@mail.tsinghua.edu.cn
Received Date: 13 May 2017
Revised Date: 24 May 2017
Accepted Date: 31 May 2017
Available Online: 2 August 2017

Figures(6)

In this review, we highlight the latest development of multi-channel microfluidic chip-mass spectrometry (chip-MS) in cell analysis and metabolite detection. Following a brief introduction about history and development of multi-channel microchip and MS combination, we will elaborate the key issues of constructing chip-MS platform interface. Then exciting progresses made in this field should be reviewed with well exemplified works, including chip-MS technology for cell introduction, pretreatment of cell secretions and cell metabolite analysis. We will also describe the development of integrated total analysis systems proposed by our group. We hope this brief review will inspire interested readers and provide knowledge about chip-MS platform in the bioanalysis field, particularly in cell analysis and metabolite identifying applications.
- Chip-MS platform,
- Interface technology,
- Cell analysis,
- Metabolite identification
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