Citation: Zhou Yanfang, Li Xingyi. Self-assembled small molecular weight hydrogels of prodrugs[J]. Chinese Chemical Letters, ;2017, 28(9): 1835-1840. doi: 10.1016/j.cclet.2017.04.033 shu

Self-assembled small molecular weight hydrogels of prodrugs

Zhou Yanfang ,
Li Xingyi ^1,,

Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China

Corresponding author: Li Xingyi, lixingyi_1984@163.com(X.Li)

Received Date: 15 March 2017
Revised Date: 19 April 2017
Accepted Date: 28 April 2017
Available Online: 10 September 2017

Figures(7)

Molecular self-assembly is very ordinary phenomenon in the biological process such as protein folding, DNA encoding and etc. Inspired by this inherent biological process, nanostructure such as nanofibers, nanosphere, and so on formed by the therapeutic agents and its derivatives that can further self-assemble into supramolecular hydrogels have attained considerable attentions in the field of drug delivery due to its favorable features such as high and precise drug payload, carrier-free and excellent biocompatibility. Additionally, the prodrug hydrogelator can be rationally designed to fine-tune over its drug release behavior and degradation in response to various biological stimulus (temperature, pH, ionic strength and etc.). This review summarized and discussed the recent advancement in the self-assembled small molecular weight hydrogels of prodrugs.
- Small molecular weight hydrogel,
- Self-assembly,
- Prodrug,
- Drug delivery
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