Citation: Xuan Qing-Qing, Wei Ya-Hui, Song Qiu-Ling. Spiro(phosphoamidite) ligand (SIPHOS)/Cu(OTf)₂-catalyzed highly regio-and stereo-selective hydroborations of internal alkynes with diborane in water[J]. Chinese Chemical Letters, ;2017, 28(6): 1163-1166. doi: 10.1016/j.cclet.2017.04.031 shu

Spiro(phosphoamidite) ligand (SIPHOS)/Cu(OTf)₂-catalyzed highly regio-and stereo-selective hydroborations of internal alkynes with diborane in water

Institute of Next Generation Matter Transformation, College of Chemical Engineering and College of Material Sciences at Huaqiao University, Xiamen 361021, China

Corresponding author: Song Qiu-Ling, qsong@hqu.edu.cn
Received Date: 1 April 2017
Revised Date: 19 April 2017
Accepted Date: 25 April 2017
Available Online: 2 June 2017

Figures(4)

The highly regio-and stereoselective hydroborations of unactivated internal alkynes with diboron compound catalyzed by Cu(OTf)₂ with spiro(phosphoamidite) as ligand in the presence of Cs₂CO₃ in water was developed. This protocol was applied efficiently in the aqueous synthesis of multi-substituted vinylboranes.
- Unactivated internal alkynes,
- Diboron compound,
- Spiro(phosphoamidite) ligand,
- Aqueous synthesis,
- Multi-substituted vinylboranes
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Spiro(phosphoamidite) ligand (SIPHOS)/Cu(OTf)2-catalyzed highly regio-and stereo-selective hydroborations of internal alkynes with diborane in water

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通讯作者: 陈斌, bchen63@163.com

Spiro(phosphoamidite) ligand (SIPHOS)/Cu(OTf)₂-catalyzed highly regio-and stereo-selective hydroborations of internal alkynes with diborane in water