Citation: Meng Xian-Hua, Guo Qing-Lan, Zhu Cheng-Gen, Shi Jian-Gong. Unprecedented C₁₉-diterpenoid alkaloid glycosides from an aqueous extract of "fu zi": Neoline 14-O-L-arabinosides with four isomeric L-anabinosyls[J]. Chinese Chemical Letters, ;2017, 28(8): 1705-1710. doi: 10.1016/j.cclet.2017.04.026 shu

Unprecedented C₁₉-diterpenoid alkaloid glycosides from an aqueous extract of "fu zi": Neoline 14-O-L-arabinosides with four isomeric L-anabinosyls

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Corresponding author: Shi Jian-Gong, shijg@imm.ac.cn
Received Date: 16 March 2017
Revised Date: 6 April 2017
Accepted Date: 20 April 2017
Available Online: 23 August 2017

Figures(3)

Four structurally unprecedented aconitane-type C₁₉-diterpenoid alkaloid glycosides with isomeric arabinosyls, named aconicarmichosides A-D (1-4), were isolated from an aqueous extract of “fu zi”, the lateral roots of Aconitum carmichaelii. Their structures were determined as neoline 14-O-α-and 14-O-β-L-arabinopyranosides (1 and 2) and 14-O-α-and 14-O-β-L-arabinofuranosides (3 and 4), by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds 1-4 represent the first examples of glycosidic diterpenoid alkaloids.
- Aconitum carmichaelii,
- Ranunculaceae,
- Fu zi,
- Aconitane alkaloid glycoside,
- Neoline 14-O-L-arabinoside,
- Aconicarmichosides A-D
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Unprecedented C19-diterpenoid alkaloid glycosides from an aqueous extract of "fu zi": Neoline 14-O-L-arabinosides with four isomeric L-anabinosyls

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通讯作者: 陈斌, bchen63@163.com

Unprecedented C₁₉-diterpenoid alkaloid glycosides from an aqueous extract of "fu zi": Neoline 14-O-L-arabinosides with four isomeric L-anabinosyls