Citation: Qi Weipeng, Xie Xiaoqiang, Zhong Tengjiang, Zhang Xingxian. Highly efficient and chemoselective direct aldol reaction of acyldiazomethane with aldehydes promoted by MgI₂ etherate[J]. Chinese Chemical Letters, ;2018, 29(1): 194-196. doi: 10.1016/j.cclet.2017.04.019 shu

Highly efficient and chemoselective direct aldol reaction of acyldiazomethane with aldehydes promoted by MgI₂ etherate

College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310032, China

Corresponding author: Zhang Xingxian, zhangxx@zjut.edu.cn
Received Date: 1 February 2017
Revised Date: 13 April 2017
Accepted Date: 17 April 2017
Available Online: 22 January 2017

Figures(1)

Direct aldol condensation of various aromatic, heteroaromatic, α, β-unsaturated aldehydes and aliphatic aldehydes with acyldiazomethane was realized using MgI₂ etherate (MgI₂ (Et₂O)_n) as a promoter in the presence of diisopropyl amine (DIPEA) in excellent yields in a short time under mild conditions with high chemoselectivity. Iodide counterion, and a non-coordinating less ploar reaction media (i.e., CH₂Cl₂) are among the critical factors for this unique reactivity.
- Chemoselective,
- Aldehyde,
- Acyldiazomethane,
- Direct aldol reaction,
- MgI₂ etherate
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沈阳化工大学材料科学与工程学院沈阳 110142

Highly efficient and chemoselective direct aldol reaction of acyldiazomethane with aldehydes promoted by MgI2 etherate

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通讯作者: 陈斌, bchen63@163.com

Highly efficient and chemoselective direct aldol reaction of acyldiazomethane with aldehydes promoted by MgI₂ etherate