Citation: Zhang Ya-Nan, Feng Yi-An, Li Zhong, Shao Xu-Sheng. Synthesis and insecticidal evaluation of phytoalexin phenalenones derivatives[J]. Chinese Chemical Letters, ;2017, 28(6): 1228-1231. doi: 10.1016/j.cclet.2017.04.003 shu

Synthesis and insecticidal evaluation of phytoalexin phenalenones derivatives

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 20037, China

Corresponding author: Shao Xu-Sheng, shaoxusheng@ecust.edu.cn

Received Date: 13 January 2017
Revised Date: 3 March 2017
Accepted Date: 4 April 2017
Available Online: 8 June 2017

Figures(2)

Phenalenone is a kind of defensive compound biosynthesized inside plants in response to the outside attack such as fungus and nematodes. A set of derivatives encompassing structural modifications on the privileged phenalenone scaffold were synthesized through introduction of phenyl and hydroxyl substitutes at 9-positon and 2-position and assessed their insecticidal activities against armyworm (Mythimna separata Walker) and cowpea aphids (Aphis craccivora). No obvious insecticidal activities of the synthesized compounds were observed against armyworm. Some of the 9-phenyl and 2-hydroxy substituted phenalenone analogues showed potential activities against cowpea aphids with 33%-41% mortality at 500 mg/L.
- Phenalenones derivatives,
- Insecticidal activities,
- Structural modifications
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