Citation: Zhang Ben-Hou, Kong Jing-Jing, Huang Yang, Lou Yue-Guang, Li Xiao-Fei, He Chun-Yang. Benign perfluoroalkylation of uracils and uracil nucleosides via visible light-induced photoredox catalysis[J]. Chinese Chemical Letters, ;2017, 28(8): 1751-1754. doi: 10.1016/j.cclet.2017.03.039 shu

Benign perfluoroalkylation of uracils and uracil nucleosides via visible light-induced photoredox catalysis

a.
School of Pharmacy, Zunyi Medical University, Zunyi 563003, China
b.
Dafeng Marine Industrial Institute of Nanjing Tech University, Yancheng 224145, China

Corresponding author: Li Xiao-Fei, lixiaofei@zmu.edu.cn He Chun-Yang, hechy2002@163.com

Received Date: 21 January 2017
Revised Date: 28 February 2017
Accepted Date: 22 March 2017
Available Online: 9 August 2017

Figures(4)

In this work, an efficient and facile method for the preparation of 5-perfluoroalkylated uracils and uracil nucleosides through visible-light-mediated reaction has been developed. The reaction processes in high efficiency under mild reaction conditions and show broad substrate scope by employing commercial available perfluoroalkyl sources, thus demonstrates high potent application in life and medicinal science.
- Uracils,
- Uracil Nucleosides,
- Blue LED,
- Photoredox catalysis,
- Perfluoroalkylation
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1.
沈阳化工大学材料科学与工程学院沈阳 110142