Citation: Yang Xue, Cheng Bin, Cheng Hang, Xu Liang, Wang Jian-Li. Rapid construction of the unique BCD ring system of tricyclo[6.2.1.0] undecane in the C₁₉-diterpenoid alkaloid aconitine[J]. Chinese Chemical Letters, ;2017, 28(8): 1788-1792. doi: 10.1016/j.cclet.2017.03.032 shu

Rapid construction of the unique BCD ring system of tricyclo[6.2.1.0] undecane in the C₁₉-diterpenoid alkaloid aconitine

Yang Xue ^a ,
Cheng Bin ^a ,
Cheng Hang ^a ,
Xu Liang ^a,, ,
Wang Jian-Li ^b,,

a.
Key Laboratory of Drug Targeting, Ministry of Education, Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, 610041, China
b.
State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, 610041, China

Corresponding author: Xu Liang, liangxu@scu.edu.cn Wang Jian-Li, wangjianli0804@163.com
Received Date: 7 February 2017
Revised Date: 20 March 2017
Accepted Date: 22 March 2017
Available Online: 24 August 2017

Figures(3)

A model study leading to the preparation of the unique tricyclo [6.2.1.0] undecane BCD ring systems of aconitine is described. The synthesis features an unprecedented diastereoselective oxidative dearomatization/dimerization/retro-DA/IMDA cascade reaction and a highly efficient Wagner-Meerwein rearrangement.
- Aconitine,
- Diterpenoid alkaloid,
- Diels-Alder reaction,
- Cascade reaction,
- Wagner-Meerwein rearrangement
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沈阳化工大学材料科学与工程学院沈阳 110142

Rapid construction of the unique BCD ring system of tricyclo[6.2.1.0] undecane in the C19-diterpenoid alkaloid aconitine

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通讯作者: 陈斌, bchen63@163.com

Rapid construction of the unique BCD ring system of tricyclo[6.2.1.0] undecane in the C₁₉-diterpenoid alkaloid aconitine