Citation: Zhou Xue, Guo Qing-Lan, Zhu Cheng-Gen, Xu Cheng-Bo, Wang Ya-Nan, Shi Jian-Gong. Gastradefurphenol, a minor 9, 9'-neolignan with a new carbon skeleton substituted by two p-hydroxybenzyls from an aqueous extract of "tian ma"[J]. Chinese Chemical Letters, ;2017, 28(6): 1185-1189. doi: 10.1016/j.cclet.2017.03.028 shu

Gastradefurphenol, a minor 9, 9'-neolignan with a new carbon skeleton substituted by two p-hydroxybenzyls from an aqueous extract of "tian ma"

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Corresponding author: Shi Jian-Gong, shijg@imm.ac.cn
Received Date: 18 January 2017
Revised Date: 19 March 2017
Accepted Date: 19 March 2017
Available Online: 21 June 2017

Figures(3)

Gastradefurphenol (1), a minor 9, 9'-neolignan with a novel carbon skeleton substituted by two p-hydroxybenzyls was isolated from an aqueous extract of the Gastrodia elata rhizomes (tian ma). Its structure was determined by extensive spectroscopic data analysis. Solvent-dependent free rotational restriction of bonds and equilibrium of two molecular states are discussed by comparison of the NMR spectroscopic data of 1 in acetone-d₆ with those in CD₃OD. A biogenetic pathway of 1 is postulated to be associated with metabolic processes of L-tyrosine.
- Gastrodia elata,
- Orchidaceae,
- 9, 9'-Neolignan,
- Gastradefurphenol,
- Minor constituent
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