Citation: Gao Na, Shang Zhi-Chun, Yu Pei, Luo Jie, Jian Kai-Li, Kong Ling-Yi, Yang Ming-Hua. Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities[J]. Chinese Chemical Letters, ;2017, 28(6): 1194-1199. doi: 10.1016/j.cclet.2017.02.022 shu

Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

Corresponding author: Kong Ling-Yi, cpu_lykong@126.com; lykong@cpu.edu.cn Yang Ming-Hua, skeepjack@163.com
Received Date: 22 November 2016
Revised Date: 3 January 2017
Accepted Date: 28 February 2017
Available Online: 2 June 2017

Figures(5)

One new indoloditerpene, 6, 7-dehydropaxilline (1), one new indole-diketopiperazine, spirotryprostatin F (2), and one new 13-membered macrolide, N-demethylmelearoride A (3), as well as 8 known alkaloids (4-11), were isolated from the solid cultures of the endophytic fungus, Penicillium brefeldianum. The structures and absolute configurations of compounds 1-3 were elucidated by comprehensive spectroscopic analysis and the circular dichroism (CD) exciton chirality method. All the metablites were evaluated for their cytotoxic activites against three human tumor cell lines. Compound 2 exhibited cytotoxicities against HepG2 and MDA-MB-231 cells with IC₅₀ values of 14.1 μmol/L and 35.5mmol/L, respectively. Compound 3 showed moderate activity against HepG2 cells with IC₅₀ values of 36.6 μmol/L.
- Penicillium brefeldianum,
- Alkaloids,
- Indoloditerpene,
- Indole-diketopiperazine,
- 13-Membered macrolide,
- Cytotoxicities
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