Citation: Jia PengJia, Ma Bu-Yun, Wei Xia-Wei, Qian Zhi-Yong. The in vitro and in vivo toxicity of gold nanoparticles[J]. Chinese Chemical Letters, ;2017, 28(4): 691-702. doi: 10.1016/j.cclet.2017.01.021 shu

The in vitro and in vivo toxicity of gold nanoparticles

a.
State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China

Author Bio:
Buyun Ma finished his five-year undergraduate study from 1992 to 1997 in Clinical Medical College of Huaxi Medical University and continued his study on imaging medicine and nuclear medicine at Sichuan University during 2001-2004 and 2008-2012.Hehas beenworking in the Department of ultrasound, West China Hospital, Sichuan University since 1997. His research is mainly engaged in ultrasound diagnosis of thyroid and breast diseases, as well as interventional ultrasound diagnosis and treatment. He has developed long-term close cooperation with the department of thyroid surgery and the department of Pathology, and he also conducted in-depth research concerning the standardized training about diagnosis of thyroid diseases, thyroid biopsy and thyroid ultrasound. He has published more than 20 articles in the international journals
Xiawei Wei received her PhD in pharmaceutics in the West China Medical School, Sichuan University, Chengdu in China. Her research was focused on the nanotoxicologyimmunotoxicology of the nanoparticles, especially the ones used as drug delivery systems. She also studied the mechanisms underlying inflammation concerned with several types of cell deaths and damage associated molecular patterns (DAMPs). She has published over 50 scientific papers in "Cell Research", "Journal of Controlled Release", "Biomaterials", and etc. And she also published two book chapters. She also serves as the associate editor of "Nanoscience and Nanotechnology Letters" and the Editorial Board Member of several journals including "Particle and Fibre Toxicology", "Scientific Reports", and "Chemico-Biological Interactions". ganic Chemistry, Chinese Academy of Sciences in 2003; obtained his Ph.D. degree under the supervision of Professor XiaoBo Liu, and then carried out postdoctoral work at Sichuan University under the supervision of Professor MingJing Tu. In 2005 he was promoted to Full Professor, and was nominated as a Leading Scientist (PI) of Sichuan University for the National 985 Project of China in 2005.His research interests are in the area of biomaterials, biomedical engineering, drug delivery system, and nanobiotechnology. Now Prof. Qian is the AsianEditor of "J Biomed Nanotechnology", Associate Editor of "Chinese Chemical Letters", and the editorial member of "Human Gene Therapy", "Journal of Biological Engineering", and "Advanced Science, Engineerin
Zhiyong Qian graduated from Chengdu Institute of Or-ganic Chemistry, Chinese Academy of Sciences in 2003; obtained his Ph.D. degree under the supervision of Professor XiaoBo Liu, and then carried out postdoctoral work at Sichuan University under the supervision of Professor MingJing Tu. In 2005 he was promoted to Full Professor, and was nominated as a Leading Scientist (PI) of Sichuan University for the National 985 Project of China in 2005.His research interests are in the area of biomaterials, biomedical engineering, drug delivery system, and nano biotechnology. Now Prof. Qian is the AsianEditor of "J Biomed Nanotechnology", Associate Editor of "Chinese Chemical Letters", and the editorial member of "Human Gene Therapy", "Journal of Biological Engineering", and "Advanced Science, Engineering and Medicine".
Corresponding author: Ma Bu-Yun, ws_mby@126.com Wei Xia-Wei, paula_8@163.com
Received Date: 18 November 2016
Revised Date: 3 January 2017
Accepted Date: 6 January 2017
Available Online: 22 April 2017

Figures(7)

Gold nanoparticles, owing to their unique physicochemical and optical properties, well-established synthetic methods and easy modifications, have been widely used in biomedical science.Therefore, for their safe and efficient applications, much attention has been given to the toxicological evaluations of gold nanoparticles in biological systems.A large number of studies focusing on this problem have been carried out during the past years.However, the researches on gold nanoparticles toxicity still remain fragmentary and even contradictory with each other.This may be caused by the variety in experimental conditions.In this review, we aim to provide a better understanding about the in vitro and in vivo toxicity of gold nanoparticles by reviewing and describing the up to date literatures related to this problem and we mainly focused on these properties such as the particle size and shape, the surface charge and modification.Besides, we also summarized the adverse effect of gold nanoparticles on immune systems and analyzed the origin of the toxicity.
- Gold nanoparticles,
- Toxicity,
- Size,
- Shape,
- Surface modification,
- In vitro,
- In vivo
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