Citation: Wu Chang-Chun, Wang Bao-Lei, Liu Jing-Bo, Wei Wei, Li Yu-Xin, Liu Yang, Chen Ming-Gui, Xiong Li-Xia, Yang Na, Li Zheng-Ming. Design, synthesis and insecticidal activities of novel anthranilic diamides containing fluorinated groups as potential ryanodine receptors activitors[J]. Chinese Chemical Letters, ;2017, 28(6): 1248-1251. doi: 10.1016/j.cclet.2017.01.019 shu

Design, synthesis and insecticidal activities of novel anthranilic diamides containing fluorinated groups as potential ryanodine receptors activitors

State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Nankai University, Tianjin 300071, China

Corresponding author: Li Zheng-Ming, nkzml@vip.163.com
Received Date: 9 October 2016
Revised Date: 30 November 2016
Accepted Date: 20 December 2016
Available Online: 20 June 2017

Figures(2)

In order to search for novel potent and environmentally benign insecticides, a series of anthranilic diamides containing various fluorinated groups were designed and synthesized. Their structures were confirmed by ¹H NMR, ¹³C NMR, ¹⁹F NMR, elemental analysis, HRMS or mass spectra. Their insecticidal activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) were evaluated. The preliminary structure-activity relationship (SAR) was discussed in detail. The biological assay indicated that most of the compounds exhibited moderate to excellent insecticidal activities. Especially, Ia showed high larvicidal activity against oriental armyworm. Meanwhile, Iu had better larvicidal effects against diamondback moth than commercial chlorantraniliprole.
- Anthranilic diamides,
- Fluorinated moieties,
- Insecticidal activities,
- Structure-activity relationship,
- Synthesis
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