Citation: Yuan Jin-Wei, Qu Ling-Bo. KMnO₄-mediated direct selective radical cross-coupling: An effective strategy for C2 arylation of quinoline N-oxide with arylboronic acids[J]. Chinese Chemical Letters, ;2017, 28(5): 981-985. doi: 10.1016/j.cclet.2017.01.016 shu

KMnO₄-mediated direct selective radical cross-coupling: An effective strategy for C2 arylation of quinoline N-oxide with arylboronic acids

Yuan Jin-Wei ^, ,
Qu Ling-Bo

School of Chemistry & Chemical Engineering, Henan University of Technology, Academician Workstation for Natural Medicinal Chemistry of Henan Province, Zhengzhou 450001, China

Corresponding author: Yuan Jin-Wei, yuanjinweigs@126.com
Received Date: 7 December 2016
Revised Date: 12 January 2017
Accepted Date: 16 January 2017
Available Online: 2 May 2017

Figures(4)

Direct C-H functionalization of quinoline N-oxides with arylboronic acids is achieved using KMnO₄ as the sole and efficient oxidative system. This method provides an efficient protocol to construct regioselectively 2-arylquinoline N-oxides via radical cross-coupling reaction in moderated to good yields under mild conditions.
- Quinoline N-oxide,
- Arylboronic acid,
- KMnO₄-mediated,
- Radical reaction,
- Arylation
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KMnO4-mediated direct selective radical cross-coupling: An effective strategy for C2 arylation of quinoline N-oxide with arylboronic acids

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通讯作者: 陈斌, bchen63@163.com

KMnO₄-mediated direct selective radical cross-coupling: An effective strategy for C2 arylation of quinoline N-oxide with arylboronic acids