Citation: Zou Zhen-Xing, Tan Gui-Shan, Zhang Guo-Gang, Yu Xia, Xu Ping-Sheng, Xu Kang-Ping. New cytotoxic apigenin derivatives from Selaginella doederleinii[J]. Chinese Chemical Letters, ;2017, 28(5): 931-934. doi: 10.1016/j.cclet.2017.01.011 shu

New cytotoxic apigenin derivatives from Selaginella doederleinii

a.
Xiangya Hospital of Central South University, Changsha 410008, China
b.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China

Corresponding author: Xu Ping-Sheng, xups2004@126.com Xu Kang-Ping, xukp395@csu.edu.cn
Received Date: 17 October 2016
Revised Date: 3 December 2016
Accepted Date: 26 December 2016
Available Online: 12 May 2017

Figures(3)

75% aqueous ethanol extract from the whole herbs of Selaginella doederleinii was isolated, and two new apigenin derivatives, doederflavones A (1) and B (2), together with ten known compounds (3-12) were characterized. Their structures were assigned by extensive spectroscopic methods including 1D/2D NMR and HR-ESIMS. Compounds 1-6 bear an aryl substituent at the C-8 or C-6 positions in ring A of apigenin skeleton. Compounds 1 and 2 were evaluated for their in vitro cytotoxicity against four human cancer cell lines A549, MCF-7, SMMC-7721, and LoVo, both of which exhibited significant cytotoxicity against A549 with IC₅₀ values of 0.82 μmol/L and 1.32 μmol/L, respectively.
- Apigenin derivatives,
- Doederflavones A and B,
- Cytotoxicity
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沈阳化工大学材料科学与工程学院沈阳 110142