Citation: Zhang Shuo, Cai Chun-Hua, Guan Zhou, Lin Jia-Ping, Zhu Xing-Yu. Fabrication of virus-like particles with strip-pattern surface: A two-step self-assembly approach[J]. Chinese Chemical Letters, ;2017, 28(4): 839-844. doi: 10.1016/j.cclet.2016.12.040 shu

Fabrication of virus-like particles with strip-pattern surface: A two-step self-assembly approach

Shanghai Key Laboratory of Advanced Polymeric Materials, State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: Cai Chun-Hua, caichunhua@ecust.edu.cn Lin Jia-Ping, jlin@ecust.edu.cn
Received Date: 5 September 2016
Revised Date: 18 October 2016
Accepted Date: 24 October 2016
Available Online: 8 April 2017

Figures(5)

Spherical nanostructures with striped patterns on the surfaces resembling the essential structures of natural virus particles were constructed through a two-step self-assembly approach of polystyrene-b-oligo(acrylic acid)(PS-b-oligo-AA)and poly(γ-benzyl L-glutamate)-b-poly(ethylene glycol)(PBLG-b-PEG)copolymer mixtures in solution.On the basis of difference in hydrophilicity and self-assembly properties of the two copolymers, the two-step self-assembly process is realized.It was found that PS-b-oligo-AA copolymers formed spherical aggregates by adding a certain amount of water into polymer solutions in the first step.In the second step, two polymer solutions were mixed and water was further added, inducing the self-assembly of PBLG-b-PEG on the surfaces of PS-b-oligo-AA spheres to form striped patterns.In-depth study was conducted for the indispensable defects of striped patterns which are dislocations and +1/2 disclinations.The influencing factors such as the mixing ratio of two copolymers and the added water content in the first step on the morphology and defects of the striped patterns were investigated.This work not only presents an idea to interpret mechanism of the cooperative self-assembly behavior, but also provides an effective approach to construct virus-like particles and other complex structures with controllable morphology.
- Virus-like particles,
- Two-step self-assembly,
- Striped patterns,
- Defects,
- Polypeptide,
- Ordered structure
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