Citation: Zhang Zhang, Lu Shi-Hong, Xu Bin, Wang Xi-Cun. A domino desulfitative coupling and decarboxylative coupling of 3, 4-dihydropyrimidine-2-thiones with copper(Ⅰ) carboxylates[J]. Chinese Chemical Letters, ;2017, 28(5): 1074-1078. doi: 10.1016/j.cclet.2016.12.034 shu

A domino desulfitative coupling and decarboxylative coupling of 3, 4-dihydropyrimidine-2-thiones with copper(Ⅰ) carboxylates

Zhang Zhang ^a,b,, ,
Lu Shi-Hong ^a,b ,
Xu Bin ^a,b ,
Wang Xi-Cun ^a,b,,

a.
Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education of China, Lanzhou 730070, China
b.
Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

Corresponding author: Zhang Zhang, zhangz@nwnu.edu.cn Wang Xi-Cun, wangxicun@nwnu.edu.cn
Received Date: 10 November 2016
Revised Date: 6 December 2016
Accepted Date: 12 December 2016
Available Online: 7 May 2017

Figures(5)

A novel and general carbon-nitrogen and carbon-carbon cross-coupling reaction between 3, 4-dihydropyrimidine-2-thiones and copper(Ⅰ) carboxylates were performed in the presence of palladium acetate. The copper(Ⅰ) carboxylates act not only as desulfurative reagents but also as sources of carbon nucleophiles. A wide array of highly substituted and functionalized pyrimidines scaffolds were synthesized in good yields.
- Dihydropyrimidinthiones,
- Desulfitative,
- Copper(Ⅰ) carboxylates,
- Decarboxylative,
- Cross-coupling
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