Citation: Ameri Mohsen, Asghari Alireza, Amoozadeh Ali, Bakherad Mohammad. A new approach for one-pot, green synthesis of new polycyclic indoles in aqueous solution[J]. Chinese Chemical Letters, ;2017, 28(5): 1031-1034. doi: 10.1016/j.cclet.2016.11.022 shu

A new approach for one-pot, green synthesis of new polycyclic indoles in aqueous solution

a.
Department of Chemistry, Semnan University, Semnan 35195-363, Iran
b.
College of Chemistry, Shahrood University of Technology, Shahrood, Iran

Corresponding author: Asghari Alireza, aasghari@semnan.ac.ir
Received Date: 29 July 2016
Revised Date: 24 October 2016
Accepted Date: 31 October 2016
Available Online: 22 May 2016

Figures(5)

Electro-oxidation of phenylamine derivatives (1a and 1b) have been studied in the presence of pyrazolidine-3,5-dione (3) as a nucleophile in phosphate buffer solution mixed with ethanol, using voltammetric and spectroscopic techniques. The obtained results indicated that the oxidized form of phenylamines (2a and 2b) participate in Michael addition type reactions with pyrazolidine-3,5-dione (3) and via ECECCCCC mechanisms convert to the corresponding new polycyclic indoles (12a and 12b). In the present study, new polycyclic indole derivatives were synthesized with good yields and high purity using a facile, one-pot and environmentally friendly electrochemical method, without any chemical catalysts, toxic solvents and hard conditions.
- Electro-oxidation,
- Phenylamine,
- Polycyclic indoles,
- Environmentally friendly,
- ECECCCCC mechanism
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