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Citation: Zhu Hu-Cheng, Chen Chun-Mei, Zhang Jin-Wen, Guo Yi, Tan Dong-Dong, Guang-ZhengWei, Jing Yang, Wang Jian-Ping, Luo Zeng-Wei, Xue Yong-Bo, Zhang Yong-Hui. Hyperisampsins N and O, two new benzoylated phloroglucinol derivatives from Hypericum sampsonii[J]. Chinese Chemical Letters, ;2017, 28(5): 986-990. doi: 10.1016/j.cclet.2016.11.014 shu

Hyperisampsins N and O, two new benzoylated phloroglucinol derivatives from Hypericum sampsonii

a.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
b.
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
c.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China

Corresponding author: Xue Yong-Bo, yongboxue@hust.edu.cn Zhang Yong-Hui, zhangyh@mails.tjmu.edu.cn

¹

Received Date: 16 August 2016
Revised Date: 28 October 2016
Accepted Date: 9 November 2016
Available Online: 18 May 2016

Figures(4)

Twenty-one benzoylated phloroglucinol derivatives bearing homoadamantyl frameworks were isolated from the aerial parts of Hypericum sampsonii, including two new ones named hyperisampsins N and O (1 and 2). The structures of 1 and 2 were elucidated by extensive NMR and mass spectrometric analyses. Their absolute configurations were further determined by using TDDFT ECD calculations. Compounds 2, 7, and 8 were evaluated for their cytotoxic activities against five human cancer cell lines, of which, 2 and 8 exhibited significant cytotoxic activities toward HL-60 cell and moderate activities against others cell lines.
- Hyperisampsin,
- PPAPs,
- ECD calculation,
- Absolute configuration
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