Citation: Parekh Nikhil M., Mistry Bhupendra M., Pandurangan Muthuraman, Shinde Surendra K., Patel Rahul V.. Investigation of anticancer potencies of newly generated Schiff base imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines[J]. Chinese Chemical Letters, ;2017, 28(3): 602-606. doi: 10.1016/j.cclet.2016.10.021 shu

Investigation of anticancer potencies of newly generated Schiff base imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines

a.
Department of Mathematics, Science & Humanities, Shroff S. R. Rotary Institute of Chemical Technology, Valia 393 135, India
b.
Organic Research Laboratory, Department of Bioresources and Food Science, College of Life and Environmental Sciences, Konkuk University, Seoul 143 701, Republic of Korea
c.
College of Life Science and Biotechnology, Department of Biological and Environmental Science, Dongguk University, 32, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-820, Republic of Korea
d.
Department of Food Science and Biotechnology, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-820, Republic of Korea

Corresponding author: Patel Rahul V., rahul.svnit11@gmail.com

Received Date: 8 June 2016
Revised Date: 23 August 2016
Accepted Date: 8 September 2016
Available Online: 15 March 2016

Figures(1)

A new series of multi-heterocyclic Schiff base was constructed starting from 4'-(imidazol-1-yl)-acetophenone which was converted to its 2-bromoethanone precursor which on cyclic condensation with thiourea yielded final thiazol-2-amine intermediate (3) to be reacted with substituted aldehydes to generate final imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines (4a-4i). New Schiff base was investigated for their in vitro cytotoxic efficacies against a panel of three human cancer cell lines namely, MCF7 (human breast cancer), HCT116 (human colon cancer), and DU145 (human prostate cancer) and one normal skin fibroblast (SF). Most of these synthetic derivatives shown important cytotoxic actions against individual carcinoma cell line collections, but weak actions against SF, which is as anticipated. Observations of SAR suggested that the difference in the characteristics of substituents attached to the Schiff base function leads to the interesting variations within pharmacological effects of resultant molecular systems. Structural analysis performed using FT-IR, ¹H NMR, ¹³C NMR spectroscopy and CHN analysis for final potent anticancer Schiff base, which warrant further investigations.
- Schiff Base,
- Imidazole,
- Thiazole,
- Anticancer,
- Drug designing,
- SAR
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1.
沈阳化工大学材料科学与工程学院沈阳 110142