Citation: Zhang Xiao-Xiao, Ma Shuang-Cheng, Mao Peng, Wang Ya-Dan. A new bisbenzylisoquinoline alkaloid from Plumulanelumbinis[J]. Chinese Chemical Letters, ;2016, 27(12): 1755-1758. doi: 10.1016/j.cclet.2016.06.051 shu

A new bisbenzylisoquinoline alkaloid from Plumulanelumbinis

a.
Beijing University of Chinese Medicine, Beijing 100029, China
b.
National Institutes for Food and Drug Control, Beijing 100050, China
c.
Shaanxi Momentum Pharmaceutical Co., LTD, Xi'an 710075, China

Corresponding author: Ma Shuang-Cheng, masc@nicpbp.org.cn
Received Date: 10 May 2016
Revised Date: 17 June 2016
Accepted Date: 27 June 2016
Available Online: 16 December 2016

Figures(5)

One new bisbenzylisoquinoline alkaloid, neferine N-oxide (1), along with three known compounds, neferine (2), liensinine (3), and isoliensinine (4), were isolated from Plumulanelumbinis-the embryo of the seed of Nelumbonucifera. Their structures were elucidated by extensive spectroscopic analysis (MS, UV, IR, NMR), and the absolute configurations were determined by experimental circulardichroism (CD) spectra. Compound 1 is a new naturally occurring bisbenzylisoquinoline alkaloid with an N-oxide functionality, and the CD spectrum of (1R, 1'R) neferine is first reported. The antioxidant activities of compounds 1-4 were evaluated using the ORAC assay, which illustrated that all these compounds showed the different levels of oxygen radical absorbance capacity.
- Plumulanelumbinis,
- Bisbenzylisoquinoline alkaloid,
- Neferine N-oxide,
- ORAC assay,
- Antioxidative activity
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沈阳化工大学材料科学与工程学院沈阳 110142