Citation: Hong-Ying Niu, Ling-Yun Su, Shi-Xia Bai, Jian-Ping Li, Xi-Lan Feng, Hai-Ming Guo. Synthesis of C8-alkyl-substituted purine analogues by direct alkylation of 8-H purines with tetrahydrofuran catalyzed by CoCl₂·6H₂O[J]. Chinese Chemical Letters, ;2017, 28(1): 105-108. doi: 10.1016/j.cclet.2016.06.009 shu

Synthesis of C8-alkyl-substituted purine analogues by direct alkylation of 8-H purines with tetrahydrofuran catalyzed by CoCl₂·6H₂O

a.
School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003, China
b.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China

Corresponding author: Hong-Ying Niu, niu_hy@163.com
Received Date: 1 April 2016
Revised Date: 25 May 2016
Accepted Date: 26 May 2016
Available Online: 10 January 2016

Figures(2)

C8-Alkyl-substituted purine analogues were synthesized through direct alkylation of 8-H purine with tetrahydrofuran in the presence of Co catalyst in one step. The reactions gave a series of novel C8-oxygen heterocyclic alkyl purine compounds in good yields under mild reaction conditions by the readily available alkylating reagents, providing a complementary route to the classical coupling reactions for the synthesis of C8-alkyl-substituted purine analogues.
- Purine,
- C-H activation,
- Alkylation,
- Tetrahydrofuran,
- Co-catalyzed
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Synthesis of C8-alkyl-substituted purine analogues by direct alkylation of 8-H purines with tetrahydrofuran catalyzed by CoCl2·6H2O

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通讯作者: 陈斌, bchen63@163.com

Synthesis of C8-alkyl-substituted purine analogues by direct alkylation of 8-H purines with tetrahydrofuran catalyzed by CoCl₂·6H₂O