Citation: Meng Tao, Fang Wu, Teng Li, Yan-Yun Li, Jing-Xing Gao. Novel chiral multidentate P₃N₄-type ligand for asymmetric transfer hydrogenation of aromatic ketones[J]. Chinese Chemical Letters, ;2017, 28(1): 97-100. doi: 10.1016/j.cclet.2016.05.028 shu

Novel chiral multidentate P₃N₄-type ligand for asymmetric transfer hydrogenation of aromatic ketones

College of Chemistry and Chemical Engineering, and National Engineering Laboratory for Green Chemical Production of Alcohols-Ethers-Esters, Xiamen University, Xiamen 361005, China

Corresponding author: Yan-Yun Li, yanyunli@xmu.edu.cn
Received Date: 11 April 2016
Revised Date: 17 May 2016
Accepted Date: 19 May 2016
Available Online: 3 January 2016

Figures(1)

Novel chiral multidentate P₃N₄-type ligand has been synthesized and characterized by NMR and HRMS. Using i-PrOH as solvent and hydrogen source, asymmetric transfer hydrogenation of various ketones was investigated. The catalyst generated in situ from chiral multidentate aminophosphine ligand (R, R, R, R)-3 and IrCl (CO)(PPh₃)₂ exhibited highly catalytic activity and excellent enantioselectivity under mild conditions, achieving the corresponding chiral alcohols with up to 99% yield and 99% ee.
- Chiral aminophosphine ligand,
- Asymmetric catalysis,
- Asymmetric transfer hydrogenation,
- Chiral alcohols,
- Aromatic ketones
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通讯作者: 陈斌, bchen63@163.com

Novel chiral multidentate P₃N₄-type ligand for asymmetric transfer hydrogenation of aromatic ketones