Citation: Jaggi Lal, Sushil K. Gupta, D. Thavaselvam, Dau D. Agarwal. Synthesis and pharmacological activity evaluation of curcumin derivatives[J]. Chinese Chemical Letters, ;2016, 27(7): 1067-1072. doi: 10.1016/j.cclet.2016.03.032 shu

Synthesis and pharmacological activity evaluation of curcumin derivatives

a.
School of Studies in Chemistry, Jiwaji University, Gwalior 474 011, India
b.
Department of Chemistry, Dr. K.N. Modi University, Newai 304 021, Rajasthan, India
c.
Microbiology Division, Defence Research Development Establishment, Gwalior 474 002, India

Corresponding author: Jaggi Lal, jaggitajagra@gmail.com
Received Date: 7 August 2015
Revised Date: 22 January 2016
Accepted Date: 24 February 2016
Available Online: 31 July 2016

Figures(4)

Curcumin 3, 4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocondensation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydrochloride as a biodegradable and nontoxic catalyst under solvent-free microwave irradiation. The synthesized product was purified by crystallization from ethanol and the process does not involve any hazardous solvent. All the synthesized curcumin derivatives 4a-o were screened for antioxidant and anti-inflammatory activity. Biological activity data of the synthesized showed that most of the synthesized compounds exhibited greater antioxidant and anti-inflammatory activity than curcumin.
- Curcumin dihydropyrimidinones/thiones/imines,
- Microwave irradiations,
- Antioxidant capacity,
- Anti-inflammatory activity
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沈阳化工大学材料科学与工程学院沈阳 110142