Citation: Zheng Jing-Wei, Ma Lin. Metal complexes of anthranilic acid derivatives: A new class of noncompetitive α-glucosidase inhibitors[J]. Chinese Chemical Letters, ;2016, 27(5): 627-630. doi: 10.1016/j.cclet.2016.01.052 shu

Metal complexes of anthranilic acid derivatives: A new class of noncompetitive α-glucosidase inhibitors

Zheng Jing-Wei ^, ,
Ma Lin

School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China

Corresponding author: Zheng Jing-Wei, zhengjnw@mail2.sysu.edu.cn
Received Date: 21 July 2015
Revised Date: 14 December 2015
Accepted Date: 23 January 2016
Available Online: 10 May 2016

Figures(2)

Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type α-glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the Ag(Ⅰ) complexes (9-16) inhibited α-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver(Ⅰ) (9) was the most potent (IC₅₀=3.21 nmol/L). Analysis of the kinetics of enzyme inhibition indicated that the mechanism of the newly prepared silver complexes was noncompetitive. The structure-activity relationships were also analyzed, and they are discussed in this report.
- α-Glucosidase,
- Anthranilic acid derivatives,
- Metal complexes,
- Noncompetitive inhibitors
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