Citation: Dhingra Ashwani Kumar, Chopra Bhawna, Dass Rameshwar, Mittal Sanjeev Kumar. Synthesis, antimicrobial and anti-inflammatory activities of some novel 5-substituted imidazolone analogs[J]. Chinese Chemical Letters, ;2016, 27(5): 707-710. doi: 10.1016/j.cclet.2016.01.049 shu

Synthesis, antimicrobial and anti-inflammatory activities of some novel 5-substituted imidazolone analogs

a.
Guru Gobind Singh College of Pharmacy, Yamuna Nagar 135001, Haryana, India
b.
Department of Pharmacy, IK Gujral Punjab Technical University, Jalandhar 144001, Punjab, India
c.
Department of Industrial Chemistry, Guru Nanak Khalsa College, Yamuna Nagar 135001, Haryana, India
d.
IEC School of Pharmacy, IEC University, Baddi 173205, Himachal Pardesh, India

Corresponding author: Dhingra Ashwani Kumar, ashwani1683@gmail.com
Received Date: 18 June 2015
Revised Date: 14 December 2015
Accepted Date: 18 January 2016
Available Online: 6 May 2016

Figures(1)

In view of potent antimicrobial and anti-inflammatory activities exhibited by 5-substituted imidazolones, a variety of novel imidazolone analogs 3a-l were synthesized by the condensation of different substituted oxazolones 1 with various aromatic amines 2. All the synthesized compounds were screened for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Several analogs produced good or moderate activities particularly against the tested Gram-positive bacteria Micrococcus luteus and Gram-negative bacteria Pseudomonas aeruginosa and. Meanwhile, compounds 3b and 3c displayed marked antifungal activity against C. albicans. In addition, the in vivo anti-inflammatory activity of the synthesized compounds was determined using the carrageenin-induced paw oedema method in rats. Two of 5-substituted imidazolone derivatives, 3k and 3d show good anti-inflammatory activity. The structures of all the newly synthesized compounds were elucidated using IR, ¹H NMR and ¹³C NMR.
- Oxazolones,
- Imidazolones,
- Antimicrobial activity,
- Anti-inflammatory activity
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