Citation: Shen Qin-Peng, Xu Xing-Meng, Li Lan, Zhao Wei, Xiang Neng-Jun, Yang Guang-Yu, Chen Yong-Kuan, Miao Ming-Ming, Liu Chun-Bo, Liu Zhi-Hua. Sesquiterpenes from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activity[J]. Chinese Chemical Letters, ;2016, 27(5): 753-756. doi: 10.1016/j.cclet.2016.01.048 shu

Sesquiterpenes from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activity

a.
Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, China
b.
School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products, Kunming Medical University, Kunming 650500, China

Corresponding author: Liu Chun-Bo, chunboliu2008@163.com Liu Zhi-Hua, zhihualiu@163.com
Received Date: 17 August 2015
Revised Date: 14 January 2016
Accepted Date: 3 February 2016
Available Online: 3 May 2016

Figures(3)

In searching for more bioactive compounds, phytochemical investigations on the acetone extract of the leaves of Nicotiana tabacum resulted in the isolation of two new sesquiterpenes, nicosesquiterpene A and B (1 and 2), along with four known sesquiterpene derivatives (3-6). Structural elucidation of 1 and 2 was performed by spectralmethods, such as HRMS, IR, UV, 1D and 2DNMR spectroscopy. Compounds 1 and 2 are the first naturally occurring pterosin-type sesquiterpene bearing an isopropyl moiety. Compounds 1-6 were also evaluated for their anti-tobaccomosaic virus (anti-TMV) activity. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 36.7% and 45.6%, respectively, which is higher than that of positive control. The other compounds also showed potential activity with inhibition rates in the range of 22.7%-29.2%.
- Sesquiterpenes,
- Anti-tobacco mosaic virus activity (Anti-TMV),
- Nicotiana tabacum,
- Structural elucidation,
- Ningnanmycin
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