Citation: Chen Ming-Hua, Lin Sheng, Wang Ya-Nan, Zhu Cheng-Gen, Li Yu-Huan, Jiang Jian-Dong, Shi Jian-Gong. Antiviral stereoisomers of 3,5-bis(2-hydroxybut-3-en-1-yl)-1,2,4-thiadiazole from the roots of Isatis indigotica[J]. Chinese Chemical Letters, ;2016, 27(5): 643-648. doi: 10.1016/j.cclet.2016.01.042 shu

Antiviral stereoisomers of 3,5-bis(2-hydroxybut-3-en-1-yl)-1,2,4-thiadiazole from the roots of Isatis indigotica

a.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
b.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Corresponding author: Shi Jian-Gong, shijg@imm.ac.cn
Received Date: 21 October 2015
Revised Date: 15 December 2015
Accepted Date: 13 January 2016
Available Online: 1 May 2016

Figures(5)

Four stereoisomers of 3,5-bis(2-hydroxybut-3-en-1-yl)-1,2,4-thiadiazole, named insatindigothiadiazoles A-D (1a-1d), were isolated from the roots of Isatis indigotica. Their structures were determined by spectroscopic analysis; specifically, the absolute configurations were assigned by using the MPA determination rule based on Δδ^RSvalues of MPA esters, and supported by electronic CD (ECD) calculations. Proposed biosynthetic pathways and preliminary investigations of the biological activities of 1a-1d against influenza virus A (H3N2), Coxsackie virus B3, and/or HSV-1 are also discussed.
- Isatis indigotica,
- Cruciferae,
- 3,5-Bis(2-hydroxybut-3-en-1-yl)-1,2,4-thiadiazole,
- Stereoisomer,
- Insatindigothiadiazoles A-D,
- Antiviral activity
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