Citation: Jing-Wei Zheng, Lin Ma. Assessment of silver(I) complexes of salicylaldehyde derivatives—histidine Schiff base as novel α-glucosidase inhibitors[J]. Chinese Chemical Letters, ;2016, 27(02): 283-286. doi: 10.1016/j.cclet.2015.11.015 shu

Assessment of silver(I) complexes of salicylaldehyde derivatives—histidine Schiff base as novel α-glucosidase inhibitors

Jing-Wei Zheng ^, ,
Lin Ma

1.
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China

Corresponding author: Jing-Wei Zheng,
Received Date: 31 March 2015
Available Online: 21 August 2015

In this study, a novel class of histidine Schiff base silver (I) complexes derived from salicylaldehyde, 1a-9a, was found to be an effective inhibitor of α-glucosidase. The results of this study showed that the newly synthesized complexes inhibited α-glucosidase through noncompetitive mechanisms; the IC₅₀ values were ranging from 0.00431 µmol L^-1 to 0.492 µmol L^-1. The structure-activity relationship was established as well. These results demonstrated that compound 7a, 5-nitro salicylaldehyde Schiff base silver complex, is the most promising α-glucosidase inhibitor with the lowest IC₅₀ value, which could be exploited as a drug candidate to alleviate postprandial hyperglycemia in the treatment of type Ⅱ diabetes mellitus. This research provided a catalyst-free, simple, and environmentally benign reaction to synthesize compounds using mechanochemistry.
- α-Glucosidase,
- Histidine schiff base silver(I) complexes,
- Type Ⅱ diabetes mellitus
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