Citation: Sakineh Asghari, Mohammad Qandalee, Vahideh Behboodi, Arastoo Nouri Gorji, Ghasem Firouzzade Pasha. Chemoselective synthesis of novel aminoindolizines using aminopyridines, acetylenic diesters and α-halo ketones[J]. Chinese Chemical Letters, ;2016, 27(03): 361-364. doi: 10.1016/j.cclet.2015.11.007 shu

Chemoselective synthesis of novel aminoindolizines using aminopyridines, acetylenic diesters and α-halo ketones

a.
a. Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar 47416-95447, Iran;
b.
b. Nano and Biotechnology Research Group, University of Mazandaran, Babolsar 47416-95447, Iran;
c.
c. Department of Biology, Garmsar Branch, Islamic Azad University, Garmsar 47416-56666, Iran

Corresponding author: Sakineh Asghari,
Received Date: 17 August 2015
Available Online: 22 October 2015

A chemoselective synthesis of novel indolizine derivatives were reported via three-component reactions of aminopyridines, acetylenic diesters and α-halo ketones. In these reactions, the zwitterion generated from aminopyridines and acetylenic diesters reacted with α-halo ketones to produce indolizine skeleton in good to high yields under mild reaction conditions.
- Aminopyridines,
- α-Halo ketones,
- Acetylenic diesters,
- Indolizine,
- Chemoselective synthesis
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