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Citation: Chao Long, Wan-Ci Luo, He-Ying Zhou, Yu-Feng Shi, Cheng-Hai Gao, Ri-Ming Huang. Isolation of toxic compounds from wild Phaeocystis globosa[J]. Chinese Chemical Letters, ;2016, 27(02): 247-250. doi: 10.1016/j.cclet.2015.10.005 shu

Isolation of toxic compounds from wild Phaeocystis globosa

a.
a. South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;
b.
b. Fangchenggang Marine Environmental Monitoring and Forecasting Center/Beilun Estuary National Nature Reserve Administration, Fangchenggang 538001, China;
c.
c. Guangdong No. 2 Provincial People's Hospital, Guangzhou 510000, China;
d.
d. Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China;
e.
e. Key Laboratory of Plant Resource Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;
f.
f. Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China

Corresponding author: Cheng-Hai Gao, Ri-Ming Huang,
Received Date: 30 June 2015
Available Online: 21 July 2015
Fund Project: Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences (No. GXKLHY13-06) (No. 2011GXNSFE018002) Foundation of Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences (No. 201210ZS). (No. GXKLHY13-06)

Two new compounds, namely taenialactam C and globorin A (1 and 2), as well as six known compounds, cornoside (3), 2-phenylethyl-b-D-glucoside (4), 3-isopropyl-5-acetoxycyclohexene-2-one-1 (5), 4-methyl-phenol (6), 5-[(2S)-2-aminobutyl]-2-methyl-phenol (7), and 1-(4-methylphenyl)-1-propanone (8) were isolated from wild Phaeocystis globosa. The structures of the new compounds were established by detailed spectroscopic analysis and by comparison with spectral data of related known compounds. The structures of the known compounds were identified by comparing their spectroscopic data with those reported in the literature. This paper also reports toxicity properties of the eight compounds against the brine shrimp Artemia salina and juvenile Epinephelus akaara fish. Some of these compounds showed significant lethality on the brine shrimp A. salina and the juvenile E. akaara fish.
- Phaeocystis globosa,
- Epinephelus akaara,
- Artemia salina,
- Toxicity
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