Citation: Nileshkumar D. Vala, Hardik H. Jardosh, Manish P. Patel. PS-TBD triggered general protocol for the synthesis of 4H-chromene, pyrano[4,3-b]pyran and pyrano[3,2-c]chromene derivatives of 1H-pyrazole and their biological activities[J]. Chinese Chemical Letters, ;2016, 27(01): 168-172. doi: 10.1016/j.cclet.2015.09.020 shu

PS-TBD triggered general protocol for the synthesis of 4H-chromene, pyrano[4,3-b]pyran and pyrano[3,2-c]chromene derivatives of 1H-pyrazole and their biological activities

1.
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388120, India

Corresponding author: Manish P. Patel,
Received Date: 9 January 2015
Available Online: 12 May 2015

A general protocol has been developed for the facile construction of titled derivatives via three component reaction between 3-substituted phenyl-1H-pyrazole-4-carbaldehyde, malononitrile and various Michael donors in presence of 5 mol% polystyrene supported 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene(PS-TBD). PS-TBD was reused for at least five runs with nearly constant catalytic activity. All compounds were screened for antimicrobial and antioxidant activities.
- PS-TBD,
- 1H-Pyrazole,
- Antimicrobial activity,
- Antioxidant activity
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