Citation: Jun Yu, Biao Yu. Synthesis of the ABC skeleton of the aglycon of Echinoside A[J]. Chinese Chemical Letters, ;2015, 26(11): 1331-1335. doi: 10.1016/j.cclet.2015.08.010 shu

Synthesis of the ABC skeleton of the aglycon of Echinoside A

Jun Yu ^a,, ,
Biao Yu ^b,,

1.
a Department of Chemistry, University of Science and Technology of China, Anhui 230026, China;
2.
b State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Corresponding author: Jun Yu, Biao Yu,
Received Date: 7 July 2015
Available Online: 3 August 2015

Echinoside A is a triterpene saponin isolated from the sea cucumber Actinopyga echinites (JAEGER), which displays potent antitumor activities in vitro and in vivo. Here, we report the synthesis of the ABC-fused ring skeleton of the aglycon of Echinoside A, with the enantiomerically pure (+)-Wieland-Miescher ketone being used as starting material and a Robinson annulation as the key reaction.
- Echinoside A
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