Citation: Sakharam B. Dongare, Hemant V. Chavan, Pravin S. Bhale, Yoginath B. Mule, Amol S. Kotmale, Babasaheb P. Bandgar. A catalyst-and solvent-free multicomponent synthesis of 7-azagramine analogues via a Mannich type reaction[J]. Chinese Chemical Letters, ;2016, 27(01): 99-103. doi: 10.1016/j.cclet.2015.07.029 shu

A catalyst-and solvent-free multicomponent synthesis of 7-azagramine analogues via a Mannich type reaction

1.
a School of Chemical Sciences, Solapur University, Solapur 413 255, Maharashtra, India;
b Department of Chemistry, A.
b Department of Chemistry, A. S. P. College, Devrukh, Dist-Ratnagiri 415 804, Maharashtra, India

Corresponding author: Babasaheb P. Bandgar,
Received Date: 26 April 2015
Available Online: 9 July 2015

A catalyst-and solvent-free protocol for the synthesis of 7-azagramine analogues is described via a three-component Mannich type reaction between 7-azaindole, aromatic aldehydes and heterocyclic amines in acceptable to excellent yields. Structures of the compounds were confirmed satisfactorily by ¹H NMR, IR, mass, TOCSY, HSQC and HMBC spectral analyses.
- Bioisosters,
- 7-Azaindole,
- Mannich reaction,
- Multicomponent reaction
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