Citation: E. Rajanarendar, K. Thirupathaiah, S. Ramakrishna, D. Nagaraju. A facile and convenient synthesis of novel imidazo[1,2-b] isoxazoles and their Mannich bases as potential biodynamic agents[J]. Chinese Chemical Letters, ;2015, 26(12): 1511-1513. doi: 10.1016/j.cclet.2015.07.024 shu

A facile and convenient synthesis of novel imidazo[1,2-b] isoxazoles and their Mannich bases as potential biodynamic agents

1.
Department of Chemistry, Kakatiya University, Warangal, TS 506009, India

Corresponding author: E. Rajanarendar,
Received Date: 25 April 2015
Available Online: 14 July 2015

A series of novel imidazo[1,2-b]isoxazoles 3 and their Mannich bases 4-6 were synthesized via convenient reactions. The reaction of 3-aminoisoxazole 1 with substituted phenacyl bromides 2 in dry ethanol afforded the corresponding 6-methyl-3-aryl imidazo[1,2-b]isoxazoles 3 in good yields. Compounds 3 on treatment with 37% formaline and secondary amines furnished the corresponding novel Mannich bases viz., 6-methyl-3-aryl-2-(morpholine/pyrrolidin-1-yl/piperidin-1-yl)-methyl-imidazo[ 1,2-b]isoxazoles 4-6.
- Imidazo[1,2-b]isoxazoles
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沈阳化工大学材料科学与工程学院沈阳 110142