Citation: Firouzeh Nemati, Seyed Hasan Nikkhah, Ali Elhampour. An environmental friendly approach for the catalyst-free synthesis of highly substituted pyrazoles promoted by ultrasonic radiation[J]. Chinese Chemical Letters, ;2015, 26(11): 1397-1399. doi: 10.1016/j.cclet.2015.07.009 shu

An environmental friendly approach for the catalyst-free synthesis of highly substituted pyrazoles promoted by ultrasonic radiation

1.
Department of Chemistry, Semnan University, Semnan 35131-19111, Iran

Corresponding author: Firouzeh Nemati,
Received Date: 14 April 2015
Available Online: 16 June 2015

A cost-effective, highly useful and eco-friendly procedure for the one-pot synthesis of highly substituted pyrazole derivatives has been developed via the reaction of various aldehydes, malononitrile and phenylhydrazine or 4-phenylthiosemicarbazide in PEG-400 and water at room temperature under ultrasound irradiation. Utilization of green solvents without a catalyst makes this methodology very interesting from economic and environmental perspectives. This method provides several advantages such as operational simplicity, use of accessible and economical starting materials and reduced environmental consequences.
- Green chemistry
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